1N6Q
HIV-1 Reverse Transcriptase Crosslinked to pre-translocation AZTMP-terminated DNA (complex N)
Summary for 1N6Q
Entry DOI | 10.2210/pdb1n6q/pdb |
Related | 1N5Y 1RTD |
Descriptor | 5'-D(*AP*T*GP*CP*AP*TP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3', 5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*AP*(ATM))-3', Reverse Transcriptase, ... (8 entities in total) |
Functional Keywords | drug resistance, hiv, nucleotide excision, reverse transcriptase, complex n, translocation, pre-translocation, transferase-immune system-dna complex, transferase/immune system/dna |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 6 |
Total formula weight | 177114.36 |
Authors | Sarafianos, S.G.,Clark Jr., A.D.,Das, K.,Tuske, S.,Birktoft, J.J.,Ilankumaran, I.,Ramesha, A.R.,Sayer, J.M.,Jerina, D.M.,Boyer, P.L.,Hughes, S.H.,Arnold, E. (deposition date: 2002-11-11, release date: 2003-01-14, Last modification date: 2021-10-27) |
Primary citation | Sarafianos, S.G.,Clark Jr., A.D.,Das, K.,Tuske, S.,Birktoft, J.J.,Ilankumaran, I.,Ramesha, A.R.,Sayer, J.M.,Jerina, D.M.,Boyer, P.L.,Hughes, S.H.,Arnold, E. Structures of HIV-1 Reverse Transcriptase with Pre- and Post-translocation AZTMP-terminated DNA Embo J., 21:6614-6624, 2002 Cited by PubMed: 12456667DOI: 10.1093/emboj/cdf637 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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