1MRL

Crystal structure of streptogramin A acetyltransferase with dalfopristin

Summary for 1MRL

Entry DOI	10.2210/pdb1mrl/pdb
Related	1MR7 1MR9
Descriptor	Streptogramin A acetyltransferase, 5-(2-DIETHYLAMINO-ETHANESULFONYL)-21-HYDROXY-10-ISOPROPYL-11,19-DIMETHYL-9,26-DIOXA-3,15,28-TRIAZA-TRICYCLO[23.2.1.00,255]OCTACOSA-1(27),12,17,19,25(28)-PENTAENE-2,8,14,23-TETRAONE (2 entities in total)
Functional Keywords	left-handed parallel beta-helix domain, transferase
Biological source	Enterococcus faecium
Total number of polymer chains	3
Total formula weight	73098.52
Authors	Kehoe, L.E.,Snidwongse, J.,Courvalin, P.,Rafferty, J.B.,Murray, I.A. (deposition date: 2002-09-18, release date: 2003-08-26, Last modification date: 2023-10-25)
Primary citation	Kehoe, L.E.,Snidwongse, J.,Courvalin, P.,Rafferty, J.B.,Murray, I.A. Structural Basis of Synercid (Quinupristin-Dalfopristin) Resistance in Gram-positive Bacterial Pathogens J.Biol.Chem., 278:29963-29970, 2003 Cited by PubMed: 12771141 DOI: 10.1074/jbc.M303766200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation