1LPQ
Human DNA Topoisomerase I (70 Kda) In Non-Covalent Complex With A 22 Base Pair DNA Duplex Containing an 8-oxoG Lesion
Summary for 1LPQ
Entry DOI | 10.2210/pdb1lpq/pdb |
Related | 1A31 1A35 1A36 1EJ9 |
Descriptor | 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*TP*(8OG)P*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', 5'-D(*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*CP*AP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3', DNA topoisomerase I, ... (4 entities in total) |
Functional Keywords | protein-dna complex, dna damage, induced conformational change, isomerase-dna complex, isomerase/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus, nucleolus: P11387 |
Total number of polymer chains | 3 |
Total formula weight | 80279.89 |
Authors | Lesher, D.T.,Pommier, Y.,Stewart, L.,Redinbo, M.R. (deposition date: 2002-05-08, release date: 2002-08-16, Last modification date: 2024-02-14) |
Primary citation | Lesher, D.T.,Pommier, Y.,Stewart, L.,Redinbo, M.R. 8-Oxoguanine rearranges the active site of human topoisomerase I Proc.Natl.Acad.Sci.USA, 99:12102-12107, 2002 Cited by PubMed: 12209008DOI: 10.1073/pnas.192282699 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.14 Å) |
Structure validation
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