1EJ9

CRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX

Summary for 1EJ9

• Entry DOI: 10.2210/pdb1ej9/pdb
• Related: 1a31 1a35 1a36
• Descriptor: DNA (5'-D(*C*AP*AP*AP*AP*AP*GP*AP*CP*TP*CP*AP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3'), DNA (5'-D(*C*AP*AP*AP*AP*AP*TP*TP*TP*TP*TP*CP*TP*GP*AP*GP*TP*CP*TP*TP*TP*TP*T)-3'), DNA TOPOISOMERASE I, ... (4 entities in total)
• Functional Keywords: protein-dna complex, type i topoisomerase, human, isomerase-dna complex, isomerase/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleolus: P11387
• Total number of polymer chains: 3
• Total formula weight: 80669.03

Authors

Redinbo, M.R.,Champoux, J.J.,Hol, W.G. (deposition date: 2000-03-01, release date: 2000-08-03, Last modification date: 2024-02-07)

• Primary citation: Redinbo, M.R.,Champoux, J.J.,Hol, W.G.; Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA.; Biochemistry, 39:6832-6840, 2000; PubMed: 10841763; DOI: 10.1021/bi992690t

Experimental method

X-RAY DIFFRACTION (2.6 Å)