1KV6

X-ray structure of the orphan nuclear receptor ERR3 ligand-binding domain in the constitutively active conformation

Summary for 1KV6

• Entry DOI: 10.2210/pdb1kv6/pdb
• Related: 1ERE 1K4W 3ERD
• Descriptor: ESTROGEN-RELATED RECEPTOR GAMMA, steroid receptor coactivator 1 (3 entities in total)
• Functional Keywords: transcriptionally active conformation in absence of ligand, structural proteomics in europe, spine, structural genomics, gene regulation
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (Probable): P62508
• Total number of polymer chains: 4
• Total formula weight: 55720.89

Authors

Greschik, H.,Wurtz, J.-M.,Sanglier, S.,Bourguet, W.,van Dorsselaer, A.,Moras, D.,Renaud, J.-P.,Structural Proteomics in Europe (SPINE) (deposition date: 2002-01-25, release date: 2003-01-25, Last modification date: 2023-08-16)

• Primary citation: Greschik, H.,Wurtz, J.-M.,Sanglier, S.,Bourguet, W.,van Dorsselaer, A.,Moras, D.,Renaud, J.-P.; Structural and Functional Evidence for Ligand-Independent Transcriptional Activation by the Estrogen-Related Receptor 3; Mol.Cell, 9:303-313, 2002; PubMed: 11864604; DOI: 10.1016/S1097-2765(02)00444-6

Experimental method

X-RAY DIFFRACTION (2.7 Å)