1JOL

THE CRYSTAL STRUCTURE OF THE BINARY COMPLEX BETWEEN FOLINIC ACID (LEUCOVORIN) AND E. COLI DIHYDROFOLATE REDUCTASE

1JOL の概要

• エントリーDOI: 10.2210/pdb1jol/pdb
• 分子名称: DIHYDROFOLATE REDUCTASE, CHLORIDE ION, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ... (5 entities in total)
• 機能のキーワード: methotrexate resistance, one-carbon metabolism, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37098.51

構造登録者

Lee, H.,Reyes, V.M.,Kraut, J. (登録日: 1996-02-25, 公開日: 1996-11-08, 最終更新日: 2024-02-07)

• 主引用文献: Lee, H.,Reyes, V.M.,Kraut, J.; Crystal structures of Escherichia coli dihydrofolate reductase complexed with 5-formyltetrahydrofolate (folinic acid) in two space groups: evidence for enolization of pteridine O4.; Biochemistry, 35:7012-7020, 1996; PubMed: 8679526; DOI: 10.1021/bi960028g

実験手法

X-RAY DIFFRACTION (1.96 Å)