1J3K
Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with WR99210, NADPH, and dUMP
Summary for 1J3K
Entry DOI | 10.2210/pdb1j3k/pdb |
Related | 1J3I 1J3J |
Descriptor | Bifunctional dihydrofolate reductase-thymidylate synthase, 6,6-DIMETHYL-1-[3-(2,4,5-TRICHLOROPHENOXY)PROPOXY]-1,6-DIHYDRO-1,3,5-TRIAZINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total) |
Functional Keywords | bifunctional, oxidoreductase, transferase |
Biological source | Plasmodium falciparum (malaria parasite P. falciparum) More |
Total number of polymer chains | 4 |
Total formula weight | 146749.09 |
Authors | Yuvaniyama, J.,Chitnumsub, P.,Kamchonwongpaisan, S.,Vanichtanankul, J.,Sirawaraporn, W.,Taylor, P.,Walkinshaw, M.,Yuthavong, Y. (deposition date: 2003-02-03, release date: 2003-05-06, Last modification date: 2023-12-27) |
Primary citation | Yuvaniyama, J.,Chitnumsub, P.,Kamchonwongpaisan, S.,Vanichtanankul, J.,Sirawaraporn, W.,Taylor, P.,Walkinshaw, M.D.,Yuthavong, Y. Insights into antifolate resistance from malarial DHFR-TS structures. NAT.STRUCT.BIOL., 10:357-365, 2003 Cited by PubMed: 12704428DOI: 10.1038/nsb921 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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