1J3J

Double mutant (C59R+S108N) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with pyrimethamine, NADPH, and dUMP

Summary for 1J3J

• Entry DOI: 10.2210/pdb1j3j/pdb
• Related: 1J3I 1J3K
• Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (6 entities in total)
• Functional Keywords: bifunctional, oxidoreductase, transferase
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum); More
• Total number of polymer chains: 4
• Total formula weight: 146459.03

Authors

Yuvaniyama, J.,Chitnumsub, P.,Kamchonwongpaisan, S.,Vanichtanankul, J.,Sirawaraporn, W.,Taylor, P.,Walkinshaw, M.,Yuthavong, Y. (deposition date: 2003-02-03, release date: 2003-05-06, Last modification date: 2023-12-27)

• Primary citation: Yuvaniyama, J.,Chitnumsub, P.,Kamchonwongpaisan, S.,Vanichtanankul, J.,Sirawaraporn, W.,Taylor, P.,Walkinshaw, M.D.,Yuthavong, Y.; Insights into antifolate resistance from malarial DHFR-TS structures.; NAT.STRUCT.BIOL., 10:357-365, 2003; PubMed: 12704428; DOI: 10.1038/nsb921

Experimental method

X-RAY DIFFRACTION (2.3 Å)