1D4L

HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR

Summary for 1D4L

• Entry DOI: 10.2210/pdb1d4l/pdb
• Related: 1b6j 1b6l 1b6n 1b6o
• Descriptor: HIV-1 PROTEASE, SULFATE ION, (10S,13S,1'R)-13-[1'-HYDROXY-2'-(N-P-AMINOBENZENESULFONYL-1''-AMINO-3''-METHYLBUTYL)ETHYL]-8,11-DIOXO-10-ISOPROPYL-2-OXA-9,12-DIAZABICYCLO [13.2.2]NONADECA-15,17,18-TRIENE, ... (4 entities in total)
• Functional Keywords: hiv, protease, inhibitor, antiviral, hydrolase
• Cellular location: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03369
• Total number of polymer chains: 2
• Total formula weight: 22436.38

Authors

Tyndall, J.D.,Reid, R.C.,Tyssen, D.P.,Jardine, D.K.,Todd, B.,Passmore, M.,March, D.R.,Pattenden, L.K.,Alewood, D.,Hu, S.H.,Alewood, P.F.,Birch, C.J.,Martin, J.L.,Fairlie, D.P. (deposition date: 1999-10-04, release date: 2000-10-11, Last modification date: 2021-11-03)

• Primary citation: Tyndall, J.D.,Reid, R.C.,Tyssen, D.P.,Jardine, D.K.,Todd, B.,Passmore, M.,March, D.R.,Pattenden, L.K.,Bergman, D.A.,Alewood, D.,Hu, S.H.,Alewood, P.F.,Birch, C.J.,Martin, J.L.,Fairlie, D.P.; Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease.; J.Med.Chem., 43:3495-3504, 2000; PubMed: 11000004; DOI: 10.1021/jm000013n

Experimental method

X-RAY DIFFRACTION (1.75 Å)