1CA8

Thrombin inhibitors with rigid tripeptidyl aldehydes

1CA8 の概要

• エントリーDOI: 10.2210/pdb1ca8/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000769
• 分子名称: Thrombin light chain, Thrombin heavy chain, HIRUGEN, ... (6 entities in total)
• 機能のキーワード: serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Hirudo medicinalis (medicinal leech); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35990.93

構造登録者

Krishnan, R.,Zhang, E.,Hakansson, K.,Arni, R.K.,Tulinsky, A.,Lim-Wilby, M.S.L.,Levy, O.E.,Semple, J.E.,Brunck, T.K. (登録日: 1998-04-27, 公開日: 1999-04-27, 最終更新日: 2023-08-09)

• 主引用文献: Krishnan, R.,Zhang, E.,Hakansson, K.,Arni, R.K.,Tulinsky, A.,Lim-Wilby, M.S.,Levy, O.E.,Semple, J.E.,Brunck, T.K.; Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes; Biochemistry, 37:12094-12103, 1998; PubMed: 9724521; DOI: 10.1021/bi980840e

実験手法

X-RAY DIFFRACTION (2.1 Å)