1C50

IDENTIFICATION AND STRUCTURAL CHARACTERIZATION OF A NOVEL ALLOSTERIC BINDING SITE OF GLYCOGEN PHOSPHORYLASE B

1C50 の概要

• エントリーDOI: 10.2210/pdb1c50/pdb
• 分子名称: PROTEIN (GLYCOGEN PHOSPHORYLASE), PYRIDOXAL-5'-PHOSPHATE, 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID [1-(4-FLUOROBENZYL)-2-(4-HYDROXYPIPERIDIN-1YL)-2-OXOETHYL]AMIDE, ... (4 entities in total)
• 機能のキーワード: glycogen metabolism, glycogen phosphorylase b, inhibition, central cavity, drug binding site, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 96524.60

構造登録者

Oikonomakos, N.G.,Skamnaki, V.T.,Tsitsanou, K.E.,Gavalas, N.G.,Johnson, L.N. (登録日: 1999-12-15, 公開日: 1999-12-23, 最終更新日: 2023-12-27)

• 主引用文献: Oikonomakos, N.G.,Skamnaki, V.T.,Tsitsanou, K.E.,Gavalas, N.G.,Johnson, L.N.; A new allosteric site in glycogen phosphorylase b as a target for drug interactions.; Structure Fold.Des., 8:575-584, 2000; PubMed: 10873856; DOI: 10.1016/S0969-2126(00)00144-1

実験手法

X-RAY DIFFRACTION (2.3 Å)