1C1S
RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES
Summary for 1C1S
Entry DOI | 10.2210/pdb1c1s/pdb |
Related | 1C1N 1C1O 1C1P 1C1Q 1C1R 1C1T 1C1U 1C1V 1C1W 1C2D 1C2E 1C2F 1C2G 1C2H 1C2I 1C2J 1C2L 1C2M |
Descriptor | TRYPSIN, CALCIUM ION, SODIUM ION, ... (6 entities in total) |
Functional Keywords | zn(ii)-mediated serine protease inhibitors, ph dependence, zn(ii) affinity stucture-based drug design, serine protease/inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Bos taurus (cattle) |
Cellular location | Secreted, extracellular space: P00760 |
Total number of polymer chains | 1 |
Total formula weight | 24007.65 |
Authors | Katz, B.A.,Luong, C. (deposition date: 1999-07-21, release date: 2000-07-26, Last modification date: 2023-12-27) |
Primary citation | Katz, B.A.,Luong, C. Recruiting Zn2+ to mediate potent, specific inhibition of serine proteases. J.Mol.Biol., 292:669-684, 1999 Cited by PubMed: 10497030DOI: 10.1006/jmbi.1999.3071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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