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1C1W

RECRUITING ZINC TO MEDIATE POTENT, SPECIFIC INHIBITION OF SERINE PROTEASES

Summary for 1C1W
Entry DOI10.2210/pdb1c1w/pdb
Related1C1N 1C1O 1C1P 1C1Q 1C1R 1C1S 1C1T 1C1U 1C1V 1C2D 1C2E 1C2F 1C2G 1C2H 1C2I 1C2J 1C2L 1C2M
DescriptorThrombin light chain, Thrombin heavy chain, Hirudin-2, ... (7 entities in total)
Functional Keywordszn(ii)-mediated serine protease inhibitors, ph dependence, zn(ii) affinity stucture-based drug design, serine protease/inhibitor, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P28504
Total number of polymer chains3
Total formula weight35953.87
Authors
Katz, B.A.,Luong, C. (deposition date: 1999-07-21, release date: 2000-07-26, Last modification date: 2023-11-15)
Primary citationKatz, B.A.,Clark, J.M.,Finer-Moore, J.S.,Jenkins, T.E.,Johnson, C.R.,Ross, M.J.,Luong, C.,Moore, W.R.,Stroud, R.M.
Design of potent selective zinc-mediated serine protease inhibitors.
Nature, 391:608-612, 1998
Cited by
PubMed: 9468142
DOI: 10.1038/35422
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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