1AFE

HUMAN ALPHA-THROMBIN INHIBITION BY CBZ-PRO-AZALYS-ONP

1AFE の概要

• エントリーDOI: 10.2210/pdb1afe/pdb
• 分子名称: ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (6 entities in total)
• 機能のキーワード: complex (serine protease-inhibitor), blood coagulation, n-carbobenzoxy-pro-alfa-azalys-p-nitrophenylester, serine proteinase inhibition, glycosylated protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35795.77

構造登録者

De Simone, G.,Balliano, G.,Milla, P.,Gallina, C.,Giordano, C.,Tarricone, C.,Rizzi, M.,Bolognesi, M.,Ascenzi, P. (登録日: 1997-03-06, 公開日: 1997-12-03, 最終更新日: 2023-08-02)

• 主引用文献: De Simone, G.,Balliano, G.,Milla, P.,Gallina, C.,Giordano, C.,Tarricone, C.,Rizzi, M.,Bolognesi, M.,Ascenzi, P.; Human alpha-thrombin inhibition by the highly selective compounds N-ethoxycarbonyl-D-Phe-Pro-alpha-azaLys p-nitrophenyl ester and N-carbobenzoxy-Pro-alpha-azaLys p-nitrophenyl ester: a kinetic, thermodynamic and X-ray crystallographic study.; J.Mol.Biol., 269:558-569, 1997; PubMed: 9217260; DOI: 10.1006/jmbi.1997.1037

実験手法

X-RAY DIFFRACTION (2 Å)