8UDU
The X-RAY co-crystal structure of human FGFR3 and Compound 17
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Fibroblast growth factor receptor 3 | polymer | 297 | 33742.0 | 2 | UniProt (P22607) Pfam (PF07714) In PDB | Homo sapiens (human) | FGFR-3 |
2 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
3 | A, B | 3-[(6-chloro-1-cyclopropyl-1H-benzimidazol-5-yl)ethynyl]-1-[(3S,5S)-5-(methoxymethyl)-1-(prop-2-enoyl)pyrrolidin-3-yl]-5-(methylamino)-1H-pyrazole-4-carboxamide | non-polymer | 524.0 | 2 | Chemie (WIQ) | |||
4 | water | water | 18.0 | 323 | Chemie (HOH) |
Sequence modifications
A, B: 455 - 756 (UniProt: P22607)
PDB | External Database | Details |
---|---|---|
Met 454 | - | initiating methionine |
- | Pro 572 | deletion |
- | Pro 573 | deletion |
- | Gly 574 | deletion |
- | Leu 575 | deletion |
- | Asp 576 | deletion |
- | Tyr 577 | deletion |
- | Ser 578 | deletion |
- | Phe 579 | deletion |
- | Asp 580 | deletion |
- | Thr 581 | deletion |
- | Cys 582 | deletion |
- | Lys 583 | deletion |
Ser 572 | Pro 584 | engineered mutation |
Gly 573 | Pro 585 | engineered mutation |
His 757 | - | expression tag |
His 758 | - | expression tag |
His 759 | - | expression tag |
His 760 | - | expression tag |
His 761 | - | expression tag |
His 762 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 67484.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1118.9 | |
All* | Total formula weight | 68603.0 |