8TTB
Cryo-EM structure of the PP2A:B55-ARPP19 complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform | polymer | 584 | 64958.0 | 1 | UniProt (P30153) Pfam (PF02985) In PDB | Homo sapiens (human) | Medium tumor antigen-associated 61 kDa protein,PP2A subunit A isoform PR65-alpha,PP2A subunit A isoform R1-alpha |
2 | B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform | polymer | 450 | 52044.3 | 1 | UniProt (P63151) In PDB | Homo sapiens (human) | |
3 | C | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform | polymer | 311 | 35845.4 | 1 | UniProt (P67775) Pfam (PF00149) In PDB | Homo sapiens (human) | PP2A-alpha,Replication protein C,RP-C |
4 | D | cAMP-regulated phosphoprotein 19 | polymer | 114 | 12620.2 | 1 | UniProt (P56211) Pfam (PF04667) In PDB | Homo sapiens (human) | |
5 | C | FE (III) ION | non-polymer | 55.8 | 1 | Chemie (FE) | |||
6 | C | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) |
Sequence modifications
A: 9 - 589 (UniProt: P30153)
B: 2 - 447 (UniProt: P63151)
C: 1 - 309 (UniProt: P67775)
D: 1 - 112 (UniProt: P56211)
PDB | External Database | Details |
---|---|---|
Gly 6 | - | expression tag |
His 7 | - | expression tag |
Met 8 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His -2 | - | expression tag |
Met -1 | - | expression tag |
Gly 0 | - | expression tag |
Ser 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
His 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
His 0 | - | expression tag |
Ala 104 | Ser 104 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 165467.9 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 121.3 | |
All* | Total formula weight | 165589.1 |