8I5G

Structure of human Nav1.7 in complex with PF-05089771

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Sodium channel subunit beta-1	polymer	192	21977.2	1	UniProt (Q07699) Pfam (PF07686) In PDB	Homo sapiens (human)
2	C	Sodium channel subunit beta-2	polymer	215	24355.9	1	UniProt (O60939) Pfam (PF07686) In PDB	Homo sapiens (human)	Nav1.7 beta2 subunit
3	A	Sodium channel protein type 9 subunit alpha	polymer	1988	226620.0	1	UniProt (Q15858) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512) In PDB	Homo sapiens (human)	Neuroendocrine sodium channel,hNE-Na,Peripheral sodium channel 1,PN1,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7
4	D, E, F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
5	B, A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
6	A	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	2	Chemie (Y01)
7	A	(3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en	non-polymer		544.8	1	Chemie (9Z9)
8	A	PF-05089771	non-polymer		500.4	1	Chemie (T70)
9	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
10	A	1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		510.7	8	Chemie (LPE)
11	A	1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		787.1	5	Chemie (PCW)
12		water	water		18.0	5	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	272953.1
Branched	Number of molecules	3
	Total formula weight	1273.2
Non-Polymers*	Number of molecules	23
	Total formula weight	11168.9
All*	Total formula weight	285395.2

*Water molecules are not included.