8HG1
The structure of MPXV polymerase holoenzyme in replicating state
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | DNA polymerase | polymer | 1031 | 119939.1 | 1 | UniProt (A0A2L0AR76) Pfam (PF08452) Pfam (PF03104) Pfam (PF08408) Pfam (PF00136) UniProt (by SIFTS) (A0A7H0DN44) In PDB | Monkeypox virus (monkeypox) | |
2 | B | E4R | polymer | 218 | 25107.7 | 1 | UniProt (Q5IXS4) UniProt (by SIFTS) (M1LL92) In PDB | Monkeypox virus (monkeypox) | MPXV-COP-095,MPXV-SL-095,MPXV-WRAIR095,MPXVgp101,Uracil-DNA glycosylase,Uracil-DNA glycosylase DNA polymerase,Uracil-DNA glycosylase interacts with A20R,DNA polymerase processivity factor |
3 | C | DNA polymerase processivity factor component A20 | polymer | 426 | 49203.9 | 1 | UniProt (Q5IXP2) Pfam (PF05941) UniProt (by SIFTS) (A0A7H0DNC0) In PDB | Monkeypox virus (monkeypox) | |
4 | P | DNA (25-MER) | polymer | 25 | 7682.0 | 1 | Monkeypox virus | ||
5 | T | DNA (38-MER) | polymer | 38 | 11677.5 | 1 | Monkeypox virus | ||
6 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
7 | A | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 1 | Chemie (TTP) |
Sequence modifications
A: 1 - 1006 (UniProt: A0A2L0AR76)
PDB | External Database | Details |
---|---|---|
Met -24 | - | initiating methionine |
Trp -23 | - | expression tag |
Ser -22 | - | expression tag |
His -21 | - | expression tag |
Pro -20 | - | expression tag |
Gln -19 | - | expression tag |
Phe -18 | - | expression tag |
Glu -17 | - | expression tag |
Lys -16 | - | expression tag |
Gly -15 | - | expression tag |
Ser -14 | - | expression tag |
Gly -13 | - | expression tag |
Ser -12 | - | expression tag |
Trp -11 | - | expression tag |
Ser -10 | - | expression tag |
His -9 | - | expression tag |
Pro -8 | - | expression tag |
Gln -7 | - | expression tag |
Phe -6 | - | expression tag |
Glu -5 | - | expression tag |
Lys -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Phe 108 | Leu 108 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 213610.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 506.5 | |
All* | Total formula weight | 214116.7 |