7ZL3
Signal peptide mimicry primes Sec61 for client-selective inhibition
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Protein transport protein Sec61 subunit alpha | polymer | 475 | 52034.1 | 1 | UniProt (A0A6P3YN15) Pfam (PF10559) Pfam (PF00344) In PDB | Ovis aries (sheep) | |
2 | B | Protein transport protein Sec61 subunit gamma | polymer | 68 | 7752.3 | 1 | UniProt (W5PP18) Pfam (PF00584) In PDB | Ovis aries (sheep) | |
3 | C | Protein transport protein Sec61 subunit beta | polymer | 29 | 2486.1 | 1 | Ovis aries (sheep) | ||
4 | E | Cyclic depsipeptide signal peptide mimic | polymer | 6 | 1102.0 | 1 | synthetic construct |
Sequence modifications
A: 1 - 475 (UniProt: A0A6P3YN15)
B: 1 - 68 (UniProt: W5PP18)
PDB | External Database | Details |
---|---|---|
- | Phe 62 | deletion |
Ala 77 | Glu 78 | conflict |
His 342 | Tyr 343 | conflict |
Val 362 | Ala 363 | conflict |
Ile 364 | Val 365 | conflict |
PDB | External Database | Details |
---|---|---|
Asp 29 | Val 29 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 63374.4 | |
All* | Total formula weight | 63374.4 |