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7ZL3

Signal peptide mimicry primes Sec61 for client-selective inhibition

Functional Information from GO Data
ChainGOidnamespacecontents
A0005048molecular_functionsignal sequence binding
A0005784cellular_componentSec61 translocon complex
A0005789cellular_componentendoplasmic reticulum membrane
A0006616biological_processSRP-dependent cotranslational protein targeting to membrane, translocation
A0008320molecular_functionprotein transmembrane transporter activity
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0031204biological_processpost-translational protein targeting to membrane, translocation
A0043022molecular_functionribosome binding
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0006605biological_processprotein targeting
B0006886biological_processintracellular protein transport
B0008320molecular_functionprotein transmembrane transporter activity
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0031204biological_processpost-translational protein targeting to membrane, translocation
B0071261cellular_componentSsh1 translocon complex
Functional Information from PROSITE/UniProt
site_idPS00755
Number of Residues20
DetailsSECY_1 Protein secY signature 1. TLMaLGIsPIVtSGLIMQLL
ChainResidueDetails
ATHR74-LEU93

site_idPS00756
Number of Residues19
DetailsSECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF
ChainResidueDetails
ALEU163-PHE181

site_idPS01067
Number of Residues29
DetailsSECE_SEC61G Protein secE/sec61-gamma signature. FvKDsIrlVkRctKPdrkEfqkiaMATAI
ChainResidueDetails
BPHE14-ILE42

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PDB entries from 2024-06-12

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