7XW5
TSHR-thyroid stimulating hormone-Gs-ML109 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 249 | 29068.9 | 1 | UniProt (P63094) Pfam (PF00503) UniProt (by SIFTS) (P63092) In PDB | Homo sapiens | |
| 2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38613.2 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
| 4 | N | Nanobody35 | polymer | 134 | 14714.3 | 1 | Lama glama | ||
| 5 | R | Thyrotropin receptor | polymer | 702 | 79920.8 | 1 | UniProt (P16473) Pfam (PF13306) Pfam (PF00001) In PDB | Homo sapiens (human) | Thyroid-stimulating hormone receptor,TSH-R |
| 6 | X | Glycoprotein hormones alpha chain | polymer | 92 | 10217.8 | 1 | UniProt (P01215) Pfam (PF00236) In PDB | Homo sapiens (human) | Anterior pituitary glycoprotein hormones common subunit alpha,Choriogonadotropin alpha chain,Chorionic gonadotrophin subunit alpha,CG-alpha,Follicle-stimulating hormone alpha chain,FSH-alpha,Follitropin alpha chain,Luteinizing hormone alpha chain,LSH-alpha,Lutropin alpha chain,Thyroid-stimulating hormone alpha chain,TSH-alpha,Thyrotropin alpha chain |
| 7 | Y | Thyrotropin subunit beta | polymer | 118 | 13518.7 | 1 | UniProt (P01222) Pfam (PF00007) In PDB | Homo sapiens (human) | Thyroid-stimulating hormone subunit beta,TSH-B,TSH-beta,Thyrotropin beta chain |
| 8 | X, R, Y | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 9 | R | ~{N}-[4-[[2-methoxy-5-[(2~{S})-5-oxidanyl-4-oxidanylidene-3-(phenylmethyl)-1,2-dihydroquinazolin-2-yl]phenyl]methoxy]phenyl]ethanamide | non-polymer | 523.6 | 1 | Chemie (HOI) | |||
| 10 | R | CHOLESTEROL | non-polymer | 386.7 | 14 | Chemie (CLR) | |||
| 11 | R | PALMITIC ACID | non-polymer | 256.4 | 5 | Chemie (PLM) |
Sequence modifications
A: 5 - 203 (PDB: 7XW5)
A: 204 - 384 (UniProt: P63094)
B: 2 - 340 (UniProt: P62873)
R: 21 - 764 (UniProt: P16473)
A: 204 - 384 (UniProt: P63094)
| PDB | External Database | Details |
|---|---|---|
| Ala 226 | Gly 226 | conflict |
| Asp 249 | Ala 249 | conflict |
| Asp 252 | Ser 252 | conflict |
| - | Met 255 | deletion |
| - | Val 256 | deletion |
| - | Ile 257 | deletion |
| - | Arg 258 | deletion |
| - | Glu 259 | deletion |
| - | Asp 260 | deletion |
| - | Asn 261 | deletion |
| - | Gln 262 | deletion |
| - | Thr 263 | deletion |
| - | Asn 264 | deletion |
| Ser 356 | Ala 366 | conflict |
| Ala 362 | Ile 372 | conflict |
| Ile 365 | Val 375 | conflict |
| PDB | External Database | Details |
|---|---|---|
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ile 281 | Ser 281 | variant |
| - | Ala 317 | deletion |
| - | Leu 318 | deletion |
| - | Asn 319 | deletion |
| - | Ser 320 | deletion |
| - | Pro 321 | deletion |
| - | Leu 322 | deletion |
| - | His 323 | deletion |
| - | Gln 324 | deletion |
| - | Glu 325 | deletion |
| - | Tyr 326 | deletion |
| - | Glu 327 | deletion |
| - | Glu 328 | deletion |
| - | Asn 329 | deletion |
| - | Leu 330 | deletion |
| - | Gly 331 | deletion |
| - | Asp 332 | deletion |
| - | Ser 333 | deletion |
| - | Ile 334 | deletion |
| - | Val 335 | deletion |
| - | Gly 336 | deletion |
| - | Tyr 337 | deletion |
| - | Lys 338 | deletion |
| - | Glu 339 | deletion |
| - | Lys 340 | deletion |
| - | Ser 341 | deletion |
| - | Lys 342 | deletion |
| - | Phe 343 | deletion |
| - | Gln 344 | deletion |
| - | Asp 345 | deletion |
| - | Thr 346 | deletion |
| - | His 347 | deletion |
| - | Asn 348 | deletion |
| - | Asn 349 | deletion |
| - | Ala 350 | deletion |
| - | His 351 | deletion |
| - | Tyr 352 | deletion |
| - | Tyr 353 | deletion |
| - | Val 354 | deletion |
| - | Phe 355 | deletion |
| - | Phe 356 | deletion |
| - | Glu 357 | deletion |
| - | Glu 358 | deletion |
| - | Gln 359 | deletion |
| - | Glu 360 | deletion |
| - | Asp 361 | deletion |
| - | Glu 362 | deletion |
| - | Ile 363 | deletion |
| - | Ile 364 | deletion |
| - | Gly 365 | deletion |
| - | Phe 366 | deletion |
| Asn 367 | Gly 367 | conflict |
| Lys 368 | Gln 368 | conflict |
| Thr 369 | Glu 369 | conflict |
| His 765 | - | expression tag |
| His 766 | - | expression tag |
| His 767 | - | expression tag |
| His 768 | - | expression tag |
| His 769 | - | expression tag |
| His 770 | - | expression tag |
| His 771 | - | expression tag |
| His 772 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 193914.8 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 8767.3 | |
| All* | Total formula weight | 202682.1 |
