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7XW5

TSHR-thyroid stimulating hormone-Gs-ML109 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0005525molecular_functionGTP binding
A0007186biological_processG protein-coupled receptor signaling pathway
A0019001molecular_functionguanyl nucleotide binding
A0031683molecular_functionG-protein beta/gamma-subunit complex binding
B0001750cellular_componentphotoreceptor outer segment
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0005834cellular_componentheterotrimeric G-protein complex
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0007213biological_processG protein-coupled acetylcholine receptor signaling pathway
B0007265biological_processRas protein signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0030159molecular_functionsignaling receptor complex adaptor activity
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0050909biological_processsensory perception of taste
B0051020molecular_functionGTPase binding
B0060041biological_processretina development in camera-type eye
B0070062cellular_componentextracellular exosome
B0071380biological_processcellular response to prostaglandin E stimulus
B0071870biological_processcellular response to catecholamine stimulus
B0097381cellular_componentphotoreceptor disc membrane
B1903561cellular_componentextracellular vesicle
G0005515molecular_functionprotein binding
G0005834cellular_componentheterotrimeric G-protein complex
G0005886cellular_componentplasma membrane
G0007165biological_processsignal transduction
G0007186biological_processG protein-coupled receptor signaling pathway
G0007191biological_processadenylate cyclase-activating dopamine receptor signaling pathway
G0016020cellular_componentmembrane
G0031681molecular_functionG-protein beta-subunit binding
G0048144biological_processfibroblast proliferation
G0070062cellular_componentextracellular exosome
G0071380biological_processcellular response to prostaglandin E stimulus
G0071870biological_processcellular response to catecholamine stimulus
R0004930molecular_functionG protein-coupled receptor activity
R0004996molecular_functionthyroid-stimulating hormone receptor activity
R0005515molecular_functionprotein binding
R0005886cellular_componentplasma membrane
R0007166biological_processcell surface receptor signaling pathway
R0007186biological_processG protein-coupled receptor signaling pathway
R0007187biological_processG protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
R0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
R0007267biological_processcell-cell signaling
R0008284biological_processpositive regulation of cell population proliferation
R0008528molecular_functionG protein-coupled peptide receptor activity
R0009755biological_processhormone-mediated signaling pathway
R0009986cellular_componentcell surface
R0016020cellular_componentmembrane
R0016323cellular_componentbasolateral plasma membrane
R0016500molecular_functionprotein-hormone receptor activity
R0038023molecular_functionsignaling receptor activity
R0038194biological_processthyroid-stimulating hormone signaling pathway
R0043235cellular_componentreceptor complex
R0044877molecular_functionprotein-containing complex binding
R0120162biological_processpositive regulation of cold-induced thermogenesis
R1904588biological_processcellular response to glycoprotein
R1905229biological_processcellular response to thyrotropin-releasing hormone
X0005179molecular_functionhormone activity
X0005515molecular_functionprotein binding
X0005576cellular_componentextracellular region
X0005615cellular_componentextracellular space
X0005796cellular_componentGolgi lumen
X0006590biological_processthyroid hormone generation
X0007186biological_processG protein-coupled receptor signaling pathway
X0008284biological_processpositive regulation of cell population proliferation
X0008406biological_processgonad development
X0009755biological_processhormone-mediated signaling pathway
X0010469biological_processregulation of signaling receptor activity
X0010893biological_processpositive regulation of steroid biosynthetic process
X0016913molecular_functionfollicle-stimulating hormone activity
X0016914cellular_componentfollicle-stimulating hormone complex
X0030335biological_processpositive regulation of cell migration
X0030878biological_processthyroid gland development
X0032275biological_processluteinizing hormone secretion
X0032870biological_processcellular response to hormone stimulus
X0035265biological_processorgan growth
X0042699biological_processfollicle-stimulating hormone signaling pathway
X0045944biological_processpositive regulation of transcription by RNA polymerase II
X0046621biological_processnegative regulation of organ growth
X0046884biological_processfollicle-stimulating hormone secretion
X0048589biological_processdevelopmental growth
X0061696cellular_componentpituitary gonadotropin complex
Y0005179molecular_functionhormone activity
Y0005576cellular_componentextracellular region
Y0005615cellular_componentextracellular space
Y0005737cellular_componentcytoplasm
Y0007186biological_processG protein-coupled receptor signaling pathway
Y0007267biological_processcell-cell signaling
Y0009653biological_processanatomical structure morphogenesis
Y0033189biological_processresponse to vitamin A
Y0043627biological_processresponse to estrogen
Y0051592biological_processresponse to calcium ion
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
ChainResidueDetails
BLEU70-SER84
BILE157-ILE171
BLEU285-ALA299

site_idPS00779
Number of Residues13
DetailsGLYCO_HORMONE_ALPHA_1 Glycoprotein hormones alpha chain signature 1. CmGCCFSRAYPTP
ChainResidueDetails
XCYS28-PRO40

site_idPS00780
Number of Residues14
DetailsGLYCO_HORMONE_ALPHA_2 Glycoprotein hormones alpha chain signature 2. NHTaChCsTCyyHK
ChainResidueDetails
XASN78-LYS91

site_idPS00261
Number of Residues7
DetailsGLYCO_HORMONE_BETA_1 Glycoprotein hormones beta chain signature 1. CAGYCmT
ChainResidueDetails
YCYS47-THR53

site_idPS00689
Number of Residues28
DetailsGLYCO_HORMONE_BETA_2 Glycoprotein hormones beta chain signature 2. PVAlsCkCgkCntdySDCiheaik..TnyC
ChainResidueDetails
YPRO98-CYS125

site_idPS00237
Number of Residues17
DetailsG_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. LSVyTLTVITLERWYaI
ChainResidueDetails
RLEU507-ILE523

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
YASN43
XASN78
RPRO611-ILE630
RLYS700-ARG710
APHE335
ATHR354
AGLY47
ASER54
ALYS328

site_idSWS_FT_FI2
Number of Residues27
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
RGLY464-GLY491

site_idSWS_FT_FI3
Number of Residues130
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
RPRO492-PHE500
RILE568-LEU587
RLEU653-PRO675

site_idSWS_FT_FI4
Number of Residues22
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
RTHR501-ILE523

site_idSWS_FT_FI5
Number of Residues22
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
RGLY545-SER567

site_idSWS_FT_FI6
Number of Residues22
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
RTHR588-ASN610

site_idSWS_FT_FI7
Number of Residues21
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
RPHE631-PRO652

site_idSWS_FT_FI8
Number of Residues23
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
RPHE676-CYS699

site_idSWS_FT_FI9
Number of Residues21
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
RVAL711-LEU732

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Sulfotyrosine => ECO:0000305|PubMed:11847099
ChainResidueDetails
RVAL435

site_idSWS_FT_FI11
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11502179, ECO:0000269|PubMed:17542669
ChainResidueDetails
RASN77
RASN113
RASN198

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17542669
ChainResidueDetails
RASN99
RASN177

site_idSWS_FT_FI13
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11502179
ChainResidueDetails
RASN352

219869

PDB entries from 2024-05-15

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