7QOX

Factor XI and Plasma Kallikrein apple domain structures reveals different kininogen bound complexes

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Plasma kallikrein heavy chain	polymer	367	41135.0	2	UniProt (P03952) Pfam (PF00024) In PDB	Homo sapiens (human)
2	D, C	Kininogen-1 light chain	polymer	29	3263.4	2	UniProt (P01042) In PDB	Homo sapiens (human)
3	A, B	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
4	A, B	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	5	Chemie (PEG)
5	A, B	2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL	non-polymer		354.4	2	Chemie (PE4)
6	A	TETRAETHYLENE GLYCOL	non-polymer		194.2	2	Chemie (PG4)
7	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
8	B	1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE	non-polymer		266.3	1	Chemie (PG6)
9		water	water		18.0	330	Chemie (HOH)

Sequence modifications

A, B: 1 - 359 (UniProt: P03952)

PDB	External Database	Details
Arg -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Ala 323	Glu 342	conflict
Ala 325	Lys 344	conflict

D, C: 564 - 591 (UniProt: P01042)

PDB	External Database	Details
Thr 563	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	88796.7
Non-Polymers*	Number of molecules	18
	Total formula weight	2889.2
All*	Total formula weight	91686.0

*Water molecules are not included.