7QNG
Structure of a MHC I-Tapasin-ERp57 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tapasin | polymer | 419 | 44882.0 | 1 | UniProt (O15533) Pfam (PF07654) In PDB | Homo sapiens (human) | TPN,TPSN,NGS-17,TAP-associated protein,TAP-binding protein |
| 2 | B | Protein disulfide-isomerase A3 | polymer | 505 | 56830.2 | 1 | UniProt (P30101) Pfam (PF00085) Pfam (PF13848) In PDB | Homo sapiens (human) | 58 kDa glucose-regulated protein,58 kDa microsomal protein,p58,Disulfide isomerase ER-60,Endoplasmic reticulum resident protein 57,ER protein 57,ERp57,Endoplasmic reticulum resident protein 60,ER protein 60,ERp60 |
| 3 | C | H-2 class I histocompatibility antigen, D-B alpha chain | polymer | 277 | 32218.9 | 1 | UniProt (P01899) Pfam (PF00129) Pfam (PF07654) In PDB | Mus musculus (house mouse) | H-2D(B) |
| 4 | D | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (human) | |
| 5 | E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence modifications
A: -19 - 399 (UniProt: O15533)
B: -23 - 481 (UniProt: P30101)
C: 1 - 276 (UniProt: P01899)
D: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Arg 240 | Thr 260 | conflict |
| Gly 400 | - | expression tag |
| Ser 401 | - | expression tag |
| Glu 402 | - | expression tag |
| Asn 403 | - | expression tag |
| Leu 404 | - | expression tag |
| Tyr 405 | - | expression tag |
| Phe 406 | - | expression tag |
| Gln 407 | - | expression tag |
| Gly 408 | - | expression tag |
| His 409 | - | expression tag |
| His 410 | - | expression tag |
| His 411 | - | expression tag |
| His 412 | - | expression tag |
| His 413 | - | expression tag |
| His 414 | - | expression tag |
| Gly 415 | - | expression tag |
| Ser 416 | - | expression tag |
| Glu 417 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 36 | Cys 60 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 145810.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| All* | Total formula weight | 146397.0 |
