7MYJ
Structure of full length human AMPK (a2b1g1) in complex with a small molecule activator MSG011
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | polymer | 565 | 63918.1 | 2 | UniProt (P54646) Pfam (PF00069) Pfam (PF21147) Pfam (PF16579) In PDB | Homo sapiens (Human) | AMPK subunit alpha-2,Acetyl-CoA carboxylase kinase,ACACA kinase,Hydroxymethylglutaryl-CoA reductase kinase,HMGCR kinase |
| 2 | B, D | 5'-AMP-activated protein kinase subunit beta-1 | polymer | 270 | 30504.3 | 2 | UniProt (Q9Y478) Pfam (PF16561) Pfam (PF04739) In PDB | Homo sapiens (Human) | AMPKb |
| 3 | E, F | 5'-AMP-activated protein kinase subunit gamma-1 | polymer | 336 | 38225.9 | 2 | UniProt (P54619) Pfam (PF00571) In PDB | Homo sapiens (Human) | AMPKg |
| 4 | A, C | (5S,6R,7R,9R,13cR,14R,16aS)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,14,15,16,16a-octahydro-5H,13cH-5,9-epoxy-4b,9a,1 5-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-14-ol | non-polymer | 470.6 | 2 | Chemie (4O7) | |||
| 5 | A, D | 5-({5-[(4'R)-4'-acetamido-2',3',4',5'-tetrahydro[1,1'-biphenyl]-4-yl]-6-chloro-1H-imidazo[4,5-b]pyridin-2-yl}oxy)-2-methylbenzoic acid | non-polymer | 517.0 | 2 | Chemie (ZQV) | |||
| 6 | E, F | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 4 | Chemie (AMP) |
Sequence modifications
A, C: 2 - 552 (UniProt: P54646)
E, F: 2 - 331 (UniProt: P54619)
| PDB | External Database | Details |
|---|---|---|
| Met -12 | - | initiating methionine |
| Gly -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Ser -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Gly 271 | Asp 271 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Ala -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Asn 0 | - | expression tag |
| Trp 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 265296.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 3364.0 | |
| All* | Total formula weight | 268660.5 |
