7LXV

Structure of human 20S proteasome with bound MPI-5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, O	Proteasome subunit alpha type-2	polymer	234	25927.5	2	UniProt (P25787) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain subunit C3,Multicatalytic endopeptidase complex subunit C3,Proteasome component C3
2	B, P	Proteasome subunit alpha type-4	polymer	261	29525.8	2	UniProt (P25789) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain subunit C9,Multicatalytic endopeptidase complex subunit C9,Proteasome component C9,Proteasome subunit L
3	C, Q	Proteasome subunit alpha type-7	polymer	248	27929.9	2	UniProt (O14818) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	Proteasome subunit RC6-1,Proteasome subunit XAPC7
4	D, R	Proteasome subunit alpha type-5	polymer	241	26436.0	2	UniProt (P28066) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain zeta chain,Multicatalytic endopeptidase complex zeta chain,Proteasome zeta chain
5	E, S	Proteasome subunit alpha type-1	polymer	263	29595.6	2	UniProt (P25786) Pfam (PF00227) Pfam (PF10584) In PDB	Homo sapiens (Human)	30 kDa prosomal protein,PROS-30,Macropain subunit C2,Multicatalytic endopeptidase complex subunit C2,Proteasome component C2,Proteasome nu chain
6	F, T	Proteasome subunit alpha type-3	polymer	255	28469.3	2	UniProt (P25788) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain subunit C8,Multicatalytic endopeptidase complex subunit C8,Proteasome component C8
7	G, U	Proteasome subunit alpha type-6	polymer	246	27432.5	2	UniProt (P60900) Pfam (PF10584) Pfam (PF00227) In PDB	Homo sapiens (Human)	27 kDa prosomal protein,p27K,Macropain iota chain,Multicatalytic endopeptidase complex iota chain,Proteasome iota chain
8	H, V	Proteasome subunit beta type-7	polymer	234	25322.0	2	UniProt (Q99436) Pfam (PF00227) Pfam (PF12465) In PDB	Homo sapiens (Human)	Macropain chain Z,Multicatalytic endopeptidase complex chain Z,Proteasome subunit Z
9	I, W	Proteasome subunit beta type-3	polymer	205	22972.9	2	UniProt (P49720) Pfam (PF00227) In PDB	Homo sapiens (Human)	Proteasome chain 13,Proteasome component C10-II,Proteasome theta chain
10	J, X	Proteasome subunit beta type-2	polymer	201	22864.3	2	UniProt (P49721) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain subunit C7-I,Multicatalytic endopeptidase complex subunit C7-I,Proteasome component C7-I
11	K, Y	Proteasome subunit beta type-5	polymer	204	22484.4	2	UniProt (P28074) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain epsilon chain,Multicatalytic endopeptidase complex epsilon chain,Proteasome chain 6,Proteasome epsilon chain,Proteasome subunit MB1,Proteasome subunit X
12	L, Z	Proteasome subunit beta type-1	polymer	213	23579.0	2	UniProt (P20618) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain subunit C5,Multicatalytic endopeptidase complex subunit C5,Proteasome component C5,Proteasome gamma chain
13	M, a	Proteasome subunit beta type-4	polymer	219	24414.7	2	UniProt (P28070) Pfam (PF00227) In PDB	Homo sapiens (Human)	26 kDa prosomal protein, PROS-26, Macropain beta chain, Multicatalytic endopeptidase complex beta chain, Proteasome beta chain,Proteasome chain 3, HsN3
14	N, b	Proteasome subunit beta type-6	polymer	205	21921.8	2	UniProt (P28072) Pfam (PF00227) In PDB	Homo sapiens (Human)	Macropain delta chain,Multicatalytic endopeptidase complex delta chain,Proteasome delta chain,Proteasome subunit Y
15	K, Y	N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide	non-polymer		352.2	2	Chemie (YHD)

Contents of the asymmetric unit

Polymers	Number of chains	28
	Total formula weight	717751.3
Non-Polymers*	Number of molecules	2
	Total formula weight	704.5
All*	Total formula weight	718455.8

*Water molecules are not included.