7KNU

CryoEM structure of the CGRP receptor with bound CGRP peptide in a detergent micelle

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	E	Receptor activity-modifying protein 1	polymer	149	17066.7	1	UniProt (O60894) Pfam (PF04901) In PDB	Homo sapiens (Human)	Calcitonin-receptor-like receptor activity-modifying protein 1,CRLR activity-modifying protein 1
2	P	Calcitonin gene-related peptide 1	polymer	37	3797.3	1	UniProt (P06881) In PDB	Homo sapiens	Alpha-type CGRP,Calcitonin gene-related peptide I,CGRP-I
3	R	Calcitonin gene-related peptide type 1 receptor	polymer	490	56274.5	1	UniProt (Q16602) Pfam (PF02793) Pfam (PF00002) In PDB	Homo sapiens (Human)	CGRP type 1 receptor,Calcitonin receptor-like receptor

Sequence modifications

E: 27 - 148 (UniProt: O60894)

PDB	External Database	Details
Met 0	-	initiating methionine
Lys 1	-	expression tag
Thr 2	-	expression tag
Ile 3	-	expression tag
Ile 4	-	expression tag
Ala 5	-	expression tag
Leu 6	-	expression tag
Ser 7	-	expression tag
Tyr 8	-	expression tag
Ile 9	-	expression tag
Phe 10	-	expression tag
Cys 11	-	expression tag
Leu 12	-	expression tag
Val 13	-	expression tag
Phe 14	-	expression tag
Ala 15	-	expression tag
Asp 16	-	expression tag
Tyr 17	-	expression tag
Lys 18	-	expression tag
Asp 19	-	expression tag
Asp 20	-	expression tag
Asp 21	-	expression tag
Asp 22	-	expression tag
Lys 23	-	expression tag
His 24	-	expression tag
Gly 25	-	expression tag
Ser 26	-	expression tag

R: 22 - 461 (UniProt: Q16602)

PDB	External Database	Details
Met -9	-	initiating methionine
Lys -8	-	expression tag
Thr -7	-	expression tag
Ile -6	-	expression tag
Ile -5	-	expression tag
Ala -4	-	expression tag
Leu -3	-	expression tag
Ser -2	-	expression tag
Tyr -1	-	expression tag
Ile 0	-	expression tag
Phe 1	-	expression tag
Cys 2	-	expression tag
Leu 3	-	expression tag
Val 4	-	expression tag
Phe 5	-	expression tag
Ala 6	-	expression tag
Asp 7	-	expression tag
Tyr 8	-	expression tag
Lys 9	-	expression tag
Asp 10	-	expression tag
Asp 11	-	expression tag
Asp 12	-	expression tag
Asp 13	-	expression tag
Leu 14	-	expression tag
Glu 15	-	expression tag
Val 16	-	expression tag
Leu 17	-	expression tag
Phe 18	-	expression tag
Gln 19	-	expression tag
Gly 20	-	expression tag
Pro 21	-	expression tag
Pro 462	-	expression tag
Ala 463	-	expression tag
Gly 464	-	expression tag
Leu 465	-	expression tag
Glu 466	-	expression tag
Val 467	-	expression tag
Leu 468	-	expression tag
Phe 469	-	expression tag
Gln 470	-	expression tag
Gly 471	-	expression tag
Pro 472	-	expression tag
His 473	-	expression tag
His 474	-	expression tag
His 475	-	expression tag
His 476	-	expression tag
His 477	-	expression tag
His 478	-	expression tag
His 479	-	expression tag
His 480	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	77138.6
All*	Total formula weight	77138.6

*Water molecules are not included.