7KNU
CryoEM structure of the CGRP receptor with bound CGRP peptide in a detergent micelle
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| E | 0001525 | biological_process | angiogenesis |
| E | 0001635 | molecular_function | calcitonin gene-related peptide receptor activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006816 | biological_process | calcium ion transport |
| E | 0006886 | biological_process | intracellular protein transport |
| E | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| E | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| E | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
| E | 0009986 | cellular_component | cell surface |
| E | 0015026 | molecular_function | coreceptor activity |
| E | 0015031 | biological_process | protein transport |
| E | 0016020 | cellular_component | membrane |
| E | 0031623 | biological_process | receptor internalization |
| E | 0032870 | biological_process | cellular response to hormone stimulus |
| E | 0043235 | cellular_component | receptor complex |
| E | 0060050 | biological_process | positive regulation of protein glycosylation |
| E | 0072659 | biological_process | protein localization to plasma membrane |
| E | 0097643 | molecular_function | amylin receptor activity |
| E | 0097647 | biological_process | amylin receptor signaling pathway |
| E | 1990406 | cellular_component | CGRP receptor complex |
| E | 1990407 | molecular_function | calcitonin gene-related peptide binding |
| E | 1990408 | biological_process | calcitonin gene-related peptide receptor signaling pathway |
| P | 0005179 | molecular_function | hormone activity |
| P | 0005576 | cellular_component | extracellular region |
| R | 0004888 | molecular_function | transmembrane signaling receptor activity |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004948 | molecular_function | calcitonin receptor activity |
| R | 0007166 | biological_process | cell surface receptor signaling pathway |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0016020 | cellular_component | membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00258 |
| Number of Residues | 15 |
| Details | CALCITONIN Calcitonin / CGRP / IAPP family signature. CDT.ATCVthrLaglL |
| Chain | Residue | Details |
| P | CYS2-LEU16 |
| site_id | PS00649 |
| Number of Residues | 25 |
| Details | G_PROTEIN_RECEP_F2_1 G-protein coupled receptors family 2 signature 1. CnrtWDgwl.CWndVaagtesmqlCP |
| Chain | Residue | Details |
| R | CYS65-PRO89 |
| site_id | PS00650 |
| Number of Residues | 16 |
| Details | G_PROTEIN_RECEP_F2_2 G-protein coupled receptors family 2 signature 2. QGLLVsTIFCFfNgeV |
| Chain | Residue | Details |
| R | GLN376-VAL391 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 168 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| R | GLU23-ILE146 | |
| R | HIS194-LYS213 | |
| R | ARG274-HIS289 | |
| R | ARG355-ASP366 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| R | ILE147-PHE166 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 116 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| R | LYS167-ARG173 | |
| R | LEU237-MET253 | |
| R | ARG314-ARG336 | |
| R | GLY389-ASN461 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| R | ILE174-ILE193 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| R | VAL214-TYR236 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| R | TRP254-ALA273 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 23 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| R | LEU290-VAL313 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 17 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| R | ALA337-TRP354 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| R | TYR367-ASN388 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9R1W5 |
| Chain | Residue | Details |
| R | SER420 | |
| R | SER445 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| R | ASN66 | |
| R | ASN118 | |
| R | ASN123 |
