7KEU
Cryo-EM structure of the Caspase-1-CARD:ASC-CARD octamer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | E, F, G, H | Caspase-1 | polymer | 85 | 9719.3 | 4 | UniProt (P29466) Pfam (PF00619) In PDB | Homo sapiens (Human) | CASP-1,Interleukin-1 beta convertase,IL-1BC,Interleukin-1 beta-converting enzyme,IL-1 beta-converting enzyme,p45 |
2 | A, B, C, D | Apoptosis-associated speck-like protein containing a CARD | polymer | 82 | 9532.8 | 4 | UniProt (Q9ULZ3) Pfam (PF00619) In PDB | Homo sapiens (Human) | hASC,Caspase recruitment domain-containing protein 5,PYD and CARD domain-containing protein,Target of methylation-induced silencing 1 |
Sequence modifications
E, F, G, H: 2 - 86 (UniProt: P29466)
A, B, C, D: 113 - 194 (UniProt: Q9ULZ3)
PDB | External Database | Details |
---|---|---|
Trp 20 | Gly 20 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 169 | Trp 169 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 77008.6 | |
All* | Total formula weight | 77008.6 |