6ZY8
Cryo-EM structure of the entire Human topoisomerase II alpha in State 2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | DNA topoisomerase 2-alpha | polymer | 1531 | 174654.4 | 2 | UniProt (P11388) Pfam (PF02518) Pfam (PF00204) Pfam (PF01751) Pfam (PF16898) Pfam (PF00521) Pfam (PF08070) In PDB | Homo sapiens (Human) | DNA topoisomerase II,alpha isozyme |
2 | D, F | DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3') | polymer | 17 | 5099.3 | 2 | Homo sapiens | ||
3 | E, C | DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3') | polymer | 13 | 4080.7 | 2 | Homo sapiens | ||
4 | A, B | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) | |||
5 | D, F | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside | non-polymer | 588.6 | 2 | Chemie (EVP) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 367668.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2189.5 | |
All* | Total formula weight | 369858.3 |