6WLW

The Vo region of human V-ATPase in state 1 (focused refinement)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	0	V-type proton ATPase 21 kDa proteolipid subunit	polymer	205	21418.2	1	UniProt (Q99437) Pfam (PF00137) In PDB	Homo sapiens (Human)	V-ATPase 21 kDa proteolipid subunit,Vacuolar proton pump 21 kDa proteolipid subunit,hATPL
2	1, 2, 3, 4, 5...	V-type proton ATPase 16 kDa proteolipid subunit	polymer	155	15743.7	9	UniProt (P27449) Pfam (PF00137) In PDB	Homo sapiens (Human)	V-ATPase 16 kDa proteolipid subunit,Vacuolar proton pump 16 kDa proteolipid subunit
3	Q	V-type proton ATPase subunit d 1	polymer	351	40369.9	1	UniProt (P61421) Pfam (PF01992) In PDB	Homo sapiens (Human)	V-ATPase subunit d 1,32 kDa accessory protein,V-ATPase 40 kDa accessory protein,V-ATPase AC39 subunit,p39,Vacuolar proton pump subunit d 1
4	R	V-type proton ATPase 116 kDa subunit a isoform 1	polymer	837	96512.4	1	UniProt (Q93050) Pfam (PF01496) In PDB	Homo sapiens (Human)	V-ATPase 116 kDa isoform a1,Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit,Vacuolar adenosine triphosphatase subunit Ac116,Vacuolar proton pump subunit 1,Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1
5	S	V-type proton ATPase subunit e 1	polymer	81	9380.3	1	UniProt (O15342) Pfam (PF05493) In PDB	Homo sapiens (Human)	V-ATPase subunit e 1,V-ATPase 9.2 kDa membrane accessory protein,V-ATPase M9.2 subunit,Vacuolar proton pump subunit e 1
6	T	Ribonuclease kappa	polymer	137	15435.2	1	UniProt (Q6P5S7) In PDB	Homo sapiens (Human)	RNase kappa
7	U	V-type proton ATPase subunit S1	polymer	470	52067.5	1	UniProt (Q15904) Pfam (PF05827) Pfam (PF20520) In PDB	Homo sapiens (Human)	V-ATPase subunit S1,Protein XAP-3,V-ATPase Ac45 subunit,V-ATPase S1 accessory protein,Vacuolar proton pump subunit S1
8	V	Renin receptor	polymer	350	39045.9	1	UniProt (O75787) Pfam (PF07850) In PDB	Homo sapiens (Human)	ATPase H(+)-transporting lysosomal accessory protein 2,ATPase H(+)-transporting lysosomal-interacting protein 2,ER-localized type I transmembrane adapter,Embryonic liver differentiation factor 10,N14F,Renin/prorenin receptor,Vacuolar ATP synthase membrane sector-associated protein M8-9,V-ATPase M8.9 subunit
9	W	beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose	branched		998.9	1	In PDB GlyTouCan (G48558GR)
10	A	beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose	branched		836.7	1	In PDB GlyTouCan (G50886AE)
11	s, u, B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
12	r	alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-3)-alpha-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1883.7	1	In PDB GlyTouCan (G71069MN)
13	0, 1, 3, R, U...	tri(methyl)-[2-[[(2~{R})-2-[(~{Z})-octadec-9-enoyl]oxy-3-[(~{E})-1-oxidanylideneoctadec-9-enoxy]propoxy]-oxidanyl-phosphoryl]oxyethyl]azanium	non-polymer		787.1	10	Chemie (WSS)
14	0, V, 2, 5, 6...	PHOSPHATIDYLETHANOLAMINE	non-polymer		734.0	13	Chemie (PTY)
15	3	(2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid	non-polymer		497.4	1	Chemie (WJS)
16	V, 5, R	CHOLESTEROL	non-polymer		386.7	4	Chemie (CLR)
17	R	1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE	non-polymer		455.4	1	Chemie (PSF)
18	R	methyl (3R,6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphate	non-polymer		534.6	1	Chemie (WJP)
19	U	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	415922.4
Branched	Number of molecules	8
	Total formula weight	5841.3
Non-Polymers*	Number of molecules	31
	Total formula weight	20669.0
All*	Total formula weight	442432.6

*Water molecules are not included.