6WLW

The Vo region of human V-ATPase in state 1 (focused refinement)

Functional Information from GO Data

Chain	GOid	namespace	contents
0	0000139	cellular_component	Golgi membrane
0	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
0	0005515	molecular_function	protein binding
0	0005765	cellular_component	lysosomal membrane
0	0005768	cellular_component	endosome
0	0005886	cellular_component	plasma membrane
0	0006811	biological_process	monoatomic ion transport
0	0007035	biological_process	vacuolar acidification
0	0007042	biological_process	lysosomal lumen acidification
0	0010008	cellular_component	endosome membrane
0	0015078	molecular_function	proton transmembrane transporter activity
0	0016020	cellular_component	membrane
0	0016241	biological_process	regulation of macroautophagy
0	0030665	cellular_component	clathrin-coated vesicle membrane
0	0030670	cellular_component	phagocytic vesicle membrane
0	0031410	cellular_component	cytoplasmic vesicle
0	0033176	cellular_component	proton-transporting V-type ATPase complex
0	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
0	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
0	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
0	0048388	biological_process	endosomal lumen acidification
0	0051452	biological_process	intracellular pH reduction
0	0061795	biological_process	Golgi lumen acidification
0	1902495	cellular_component	transmembrane transporter complex
0	1902600	biological_process	proton transmembrane transport
1	0000139	cellular_component	Golgi membrane
1	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
1	0005515	molecular_function	protein binding
1	0005765	cellular_component	lysosomal membrane
1	0005886	cellular_component	plasma membrane
1	0005925	cellular_component	focal adhesion
1	0006811	biological_process	monoatomic ion transport
1	0007035	biological_process	vacuolar acidification
1	0007042	biological_process	lysosomal lumen acidification
1	0010008	cellular_component	endosome membrane
1	0015078	molecular_function	proton transmembrane transporter activity
1	0015986	biological_process	proton motive force-driven ATP synthesis
1	0016020	cellular_component	membrane
1	0016241	biological_process	regulation of macroautophagy
1	0030177	biological_process	positive regulation of Wnt signaling pathway
1	0030665	cellular_component	clathrin-coated vesicle membrane
1	0030670	cellular_component	phagocytic vesicle membrane
1	0030672	cellular_component	synaptic vesicle membrane
1	0031410	cellular_component	cytoplasmic vesicle
1	0031625	molecular_function	ubiquitin protein ligase binding
1	0033176	cellular_component	proton-transporting V-type ATPase complex
1	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
1	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
1	0035577	cellular_component	azurophil granule membrane
1	0045202	cellular_component	synapse
1	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
1	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
1	0048388	biological_process	endosomal lumen acidification
1	0051452	biological_process	intracellular pH reduction
1	0061795	biological_process	Golgi lumen acidification
1	0070062	cellular_component	extracellular exosome
1	0070821	cellular_component	tertiary granule membrane
1	0101003	cellular_component	ficolin-1-rich granule membrane
1	1902495	cellular_component	transmembrane transporter complex
1	1902600	biological_process	proton transmembrane transport
2	0000139	cellular_component	Golgi membrane
2	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
2	0005515	molecular_function	protein binding
2	0005765	cellular_component	lysosomal membrane
2	0005886	cellular_component	plasma membrane
2	0005925	cellular_component	focal adhesion
2	0006811	biological_process	monoatomic ion transport
2	0007035	biological_process	vacuolar acidification
2	0007042	biological_process	lysosomal lumen acidification
2	0010008	cellular_component	endosome membrane
2	0015078	molecular_function	proton transmembrane transporter activity
2	0015986	biological_process	proton motive force-driven ATP synthesis
2	0016020	cellular_component	membrane
2	0016241	biological_process	regulation of macroautophagy
2	0030177	biological_process	positive regulation of Wnt signaling pathway
2	0030665	cellular_component	clathrin-coated vesicle membrane
2	0030670	cellular_component	phagocytic vesicle membrane
2	0030672	cellular_component	synaptic vesicle membrane
2	0031410	cellular_component	cytoplasmic vesicle
2	0031625	molecular_function	ubiquitin protein ligase binding
2	0033176	cellular_component	proton-transporting V-type ATPase complex
2	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
2	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
2	0035577	cellular_component	azurophil granule membrane
2	0045202	cellular_component	synapse
2	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
2	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
2	0048388	biological_process	endosomal lumen acidification
2	0051452	biological_process	intracellular pH reduction
2	0061795	biological_process	Golgi lumen acidification
2	0070062	cellular_component	extracellular exosome
2	0070821	cellular_component	tertiary granule membrane
2	0101003	cellular_component	ficolin-1-rich granule membrane
2	1902495	cellular_component	transmembrane transporter complex
2	1902600	biological_process	proton transmembrane transport
3	0000139	cellular_component	Golgi membrane
3	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
3	0005515	molecular_function	protein binding
3	0005765	cellular_component	lysosomal membrane
3	0005886	cellular_component	plasma membrane
3	0005925	cellular_component	focal adhesion
3	0006811	biological_process	monoatomic ion transport
3	0007035	biological_process	vacuolar acidification
3	0007042	biological_process	lysosomal lumen acidification
3	0010008	cellular_component	endosome membrane
3	0015078	molecular_function	proton transmembrane transporter activity
3	0015986	biological_process	proton motive force-driven ATP synthesis
3	0016020	cellular_component	membrane
3	0016241	biological_process	regulation of macroautophagy
3	0030177	biological_process	positive regulation of Wnt signaling pathway
3	0030665	cellular_component	clathrin-coated vesicle membrane
3	0030670	cellular_component	phagocytic vesicle membrane
3	0030672	cellular_component	synaptic vesicle membrane
3	0031410	cellular_component	cytoplasmic vesicle
3	0031625	molecular_function	ubiquitin protein ligase binding
3	0033176	cellular_component	proton-transporting V-type ATPase complex
3	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
3	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
3	0035577	cellular_component	azurophil granule membrane
3	0045202	cellular_component	synapse
3	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
3	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
3	0048388	biological_process	endosomal lumen acidification
3	0051452	biological_process	intracellular pH reduction
3	0061795	biological_process	Golgi lumen acidification
3	0070062	cellular_component	extracellular exosome
3	0070821	cellular_component	tertiary granule membrane
3	0101003	cellular_component	ficolin-1-rich granule membrane
3	1902495	cellular_component	transmembrane transporter complex
3	1902600	biological_process	proton transmembrane transport
4	0000139	cellular_component	Golgi membrane
4	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
4	0005515	molecular_function	protein binding
4	0005765	cellular_component	lysosomal membrane
4	0005886	cellular_component	plasma membrane
4	0005925	cellular_component	focal adhesion
4	0006811	biological_process	monoatomic ion transport
4	0007035	biological_process	vacuolar acidification
4	0007042	biological_process	lysosomal lumen acidification
4	0010008	cellular_component	endosome membrane
4	0015078	molecular_function	proton transmembrane transporter activity
4	0015986	biological_process	proton motive force-driven ATP synthesis
4	0016020	cellular_component	membrane
4	0016241	biological_process	regulation of macroautophagy
4	0030177	biological_process	positive regulation of Wnt signaling pathway
4	0030665	cellular_component	clathrin-coated vesicle membrane
4	0030670	cellular_component	phagocytic vesicle membrane
4	0030672	cellular_component	synaptic vesicle membrane
4	0031410	cellular_component	cytoplasmic vesicle
4	0031625	molecular_function	ubiquitin protein ligase binding
4	0033176	cellular_component	proton-transporting V-type ATPase complex
4	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
4	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
4	0035577	cellular_component	azurophil granule membrane
4	0045202	cellular_component	synapse
4	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
4	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
4	0048388	biological_process	endosomal lumen acidification
4	0051452	biological_process	intracellular pH reduction
4	0061795	biological_process	Golgi lumen acidification
4	0070062	cellular_component	extracellular exosome
4	0070821	cellular_component	tertiary granule membrane
4	0101003	cellular_component	ficolin-1-rich granule membrane
4	1902495	cellular_component	transmembrane transporter complex
4	1902600	biological_process	proton transmembrane transport
5	0000139	cellular_component	Golgi membrane
5	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
5	0005515	molecular_function	protein binding
5	0005765	cellular_component	lysosomal membrane
5	0005886	cellular_component	plasma membrane
5	0005925	cellular_component	focal adhesion
5	0006811	biological_process	monoatomic ion transport
5	0007035	biological_process	vacuolar acidification
5	0007042	biological_process	lysosomal lumen acidification
5	0010008	cellular_component	endosome membrane
5	0015078	molecular_function	proton transmembrane transporter activity
5	0015986	biological_process	proton motive force-driven ATP synthesis
5	0016020	cellular_component	membrane
5	0016241	biological_process	regulation of macroautophagy
5	0030177	biological_process	positive regulation of Wnt signaling pathway
5	0030665	cellular_component	clathrin-coated vesicle membrane
5	0030670	cellular_component	phagocytic vesicle membrane
5	0030672	cellular_component	synaptic vesicle membrane
5	0031410	cellular_component	cytoplasmic vesicle
5	0031625	molecular_function	ubiquitin protein ligase binding
5	0033176	cellular_component	proton-transporting V-type ATPase complex
5	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
5	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
5	0035577	cellular_component	azurophil granule membrane
5	0045202	cellular_component	synapse
5	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
5	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
5	0048388	biological_process	endosomal lumen acidification
5	0051452	biological_process	intracellular pH reduction
5	0061795	biological_process	Golgi lumen acidification
5	0070062	cellular_component	extracellular exosome
5	0070821	cellular_component	tertiary granule membrane
5	0101003	cellular_component	ficolin-1-rich granule membrane
5	1902495	cellular_component	transmembrane transporter complex
5	1902600	biological_process	proton transmembrane transport
6	0000139	cellular_component	Golgi membrane
6	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
6	0005515	molecular_function	protein binding
6	0005765	cellular_component	lysosomal membrane
6	0005886	cellular_component	plasma membrane
6	0005925	cellular_component	focal adhesion
6	0006811	biological_process	monoatomic ion transport
6	0007035	biological_process	vacuolar acidification
6	0007042	biological_process	lysosomal lumen acidification
6	0010008	cellular_component	endosome membrane
6	0015078	molecular_function	proton transmembrane transporter activity
6	0015986	biological_process	proton motive force-driven ATP synthesis
6	0016020	cellular_component	membrane
6	0016241	biological_process	regulation of macroautophagy
6	0030177	biological_process	positive regulation of Wnt signaling pathway
6	0030665	cellular_component	clathrin-coated vesicle membrane
6	0030670	cellular_component	phagocytic vesicle membrane
6	0030672	cellular_component	synaptic vesicle membrane
6	0031410	cellular_component	cytoplasmic vesicle
6	0031625	molecular_function	ubiquitin protein ligase binding
6	0033176	cellular_component	proton-transporting V-type ATPase complex
6	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
6	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
6	0035577	cellular_component	azurophil granule membrane
6	0045202	cellular_component	synapse
6	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
6	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
6	0048388	biological_process	endosomal lumen acidification
6	0051452	biological_process	intracellular pH reduction
6	0061795	biological_process	Golgi lumen acidification
6	0070062	cellular_component	extracellular exosome
6	0070821	cellular_component	tertiary granule membrane
6	0101003	cellular_component	ficolin-1-rich granule membrane
6	1902495	cellular_component	transmembrane transporter complex
6	1902600	biological_process	proton transmembrane transport
7	0000139	cellular_component	Golgi membrane
7	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
7	0005515	molecular_function	protein binding
7	0005765	cellular_component	lysosomal membrane
7	0005886	cellular_component	plasma membrane
7	0005925	cellular_component	focal adhesion
7	0006811	biological_process	monoatomic ion transport
7	0007035	biological_process	vacuolar acidification
7	0007042	biological_process	lysosomal lumen acidification
7	0010008	cellular_component	endosome membrane
7	0015078	molecular_function	proton transmembrane transporter activity
7	0015986	biological_process	proton motive force-driven ATP synthesis
7	0016020	cellular_component	membrane
7	0016241	biological_process	regulation of macroautophagy
7	0030177	biological_process	positive regulation of Wnt signaling pathway
7	0030665	cellular_component	clathrin-coated vesicle membrane
7	0030670	cellular_component	phagocytic vesicle membrane
7	0030672	cellular_component	synaptic vesicle membrane
7	0031410	cellular_component	cytoplasmic vesicle
7	0031625	molecular_function	ubiquitin protein ligase binding
7	0033176	cellular_component	proton-transporting V-type ATPase complex
7	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
7	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
7	0035577	cellular_component	azurophil granule membrane
7	0045202	cellular_component	synapse
7	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
7	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
7	0048388	biological_process	endosomal lumen acidification
7	0051452	biological_process	intracellular pH reduction
7	0061795	biological_process	Golgi lumen acidification
7	0070062	cellular_component	extracellular exosome
7	0070821	cellular_component	tertiary granule membrane
7	0101003	cellular_component	ficolin-1-rich granule membrane
7	1902495	cellular_component	transmembrane transporter complex
7	1902600	biological_process	proton transmembrane transport
8	0000139	cellular_component	Golgi membrane
8	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
8	0005515	molecular_function	protein binding
8	0005765	cellular_component	lysosomal membrane
8	0005886	cellular_component	plasma membrane
8	0005925	cellular_component	focal adhesion
8	0006811	biological_process	monoatomic ion transport
8	0007035	biological_process	vacuolar acidification
8	0007042	biological_process	lysosomal lumen acidification
8	0010008	cellular_component	endosome membrane
8	0015078	molecular_function	proton transmembrane transporter activity
8	0015986	biological_process	proton motive force-driven ATP synthesis
8	0016020	cellular_component	membrane
8	0016241	biological_process	regulation of macroautophagy
8	0030177	biological_process	positive regulation of Wnt signaling pathway
8	0030665	cellular_component	clathrin-coated vesicle membrane
8	0030670	cellular_component	phagocytic vesicle membrane
8	0030672	cellular_component	synaptic vesicle membrane
8	0031410	cellular_component	cytoplasmic vesicle
8	0031625	molecular_function	ubiquitin protein ligase binding
8	0033176	cellular_component	proton-transporting V-type ATPase complex
8	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
8	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
8	0035577	cellular_component	azurophil granule membrane
8	0045202	cellular_component	synapse
8	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
8	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
8	0048388	biological_process	endosomal lumen acidification
8	0051452	biological_process	intracellular pH reduction
8	0061795	biological_process	Golgi lumen acidification
8	0070062	cellular_component	extracellular exosome
8	0070821	cellular_component	tertiary granule membrane
8	0101003	cellular_component	ficolin-1-rich granule membrane
8	1902495	cellular_component	transmembrane transporter complex
8	1902600	biological_process	proton transmembrane transport
9	0000139	cellular_component	Golgi membrane
9	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
9	0005515	molecular_function	protein binding
9	0005765	cellular_component	lysosomal membrane
9	0005886	cellular_component	plasma membrane
9	0005925	cellular_component	focal adhesion
9	0006811	biological_process	monoatomic ion transport
9	0007035	biological_process	vacuolar acidification
9	0007042	biological_process	lysosomal lumen acidification
9	0010008	cellular_component	endosome membrane
9	0015078	molecular_function	proton transmembrane transporter activity
9	0015986	biological_process	proton motive force-driven ATP synthesis
9	0016020	cellular_component	membrane
9	0016241	biological_process	regulation of macroautophagy
9	0030177	biological_process	positive regulation of Wnt signaling pathway
9	0030665	cellular_component	clathrin-coated vesicle membrane
9	0030670	cellular_component	phagocytic vesicle membrane
9	0030672	cellular_component	synaptic vesicle membrane
9	0031410	cellular_component	cytoplasmic vesicle
9	0031625	molecular_function	ubiquitin protein ligase binding
9	0033176	cellular_component	proton-transporting V-type ATPase complex
9	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
9	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
9	0035577	cellular_component	azurophil granule membrane
9	0045202	cellular_component	synapse
9	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
9	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
9	0048388	biological_process	endosomal lumen acidification
9	0051452	biological_process	intracellular pH reduction
9	0061795	biological_process	Golgi lumen acidification
9	0070062	cellular_component	extracellular exosome
9	0070821	cellular_component	tertiary granule membrane
9	0101003	cellular_component	ficolin-1-rich granule membrane
9	1902495	cellular_component	transmembrane transporter complex
9	1902600	biological_process	proton transmembrane transport
Q	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
Q	0005515	molecular_function	protein binding
Q	0005764	cellular_component	lysosome
Q	0005765	cellular_component	lysosomal membrane
Q	0005768	cellular_component	endosome
Q	0005769	cellular_component	early endosome
Q	0005813	cellular_component	centrosome
Q	0006811	biological_process	monoatomic ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0007034	biological_process	vacuolar transport
Q	0007035	biological_process	vacuolar acidification
Q	0008021	cellular_component	synaptic vesicle
Q	0010008	cellular_component	endosome membrane
Q	0016020	cellular_component	membrane
Q	0016241	biological_process	regulation of macroautophagy
Q	0016324	cellular_component	apical plasma membrane
Q	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
Q	0030030	biological_process	cell projection organization
Q	0030665	cellular_component	clathrin-coated vesicle membrane
Q	0030670	cellular_component	phagocytic vesicle membrane
Q	0030672	cellular_component	synaptic vesicle membrane
Q	0031410	cellular_component	cytoplasmic vesicle
Q	0032991	cellular_component	protein-containing complex
Q	0033176	cellular_component	proton-transporting V-type ATPase complex
Q	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
Q	0033181	cellular_component	plasma membrane proton-transporting V-type ATPase complex
Q	0036295	biological_process	cellular response to increased oxygen levels
Q	0043679	cellular_component	axon terminus
Q	0044877	molecular_function	protein-containing complex binding
Q	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
Q	0060271	biological_process	cilium assembly
Q	0070062	cellular_component	extracellular exosome
Q	0097401	biological_process	synaptic vesicle lumen acidification
Q	1902495	cellular_component	transmembrane transporter complex
Q	1902600	biological_process	proton transmembrane transport
R	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
R	0005515	molecular_function	protein binding
R	0005737	cellular_component	cytoplasm
R	0005765	cellular_component	lysosomal membrane
R	0005794	cellular_component	Golgi apparatus
R	0005829	cellular_component	cytosol
R	0005886	cellular_component	plasma membrane
R	0006811	biological_process	monoatomic ion transport
R	0007035	biological_process	vacuolar acidification
R	0007042	biological_process	lysosomal lumen acidification
R	0010008	cellular_component	endosome membrane
R	0016020	cellular_component	membrane
R	0016241	biological_process	regulation of macroautophagy
R	0016471	cellular_component	vacuolar proton-transporting V-type ATPase complex
R	0016607	cellular_component	nuclear speck
R	0030665	cellular_component	clathrin-coated vesicle membrane
R	0030667	cellular_component	secretory granule membrane
R	0030670	cellular_component	phagocytic vesicle membrane
R	0030672	cellular_component	synaptic vesicle membrane
R	0031410	cellular_component	cytoplasmic vesicle
R	0033176	cellular_component	proton-transporting V-type ATPase complex
R	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
R	0042470	cellular_component	melanosome
R	0043229	cellular_component	intracellular organelle
R	0043231	cellular_component	intracellular membrane-bounded organelle
R	0045202	cellular_component	synapse
R	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
R	0048388	biological_process	endosomal lumen acidification
R	0048471	cellular_component	perinuclear region of cytoplasm
R	0051117	molecular_function	ATPase binding
R	0070062	cellular_component	extracellular exosome
R	0097401	biological_process	synaptic vesicle lumen acidification
R	0101003	cellular_component	ficolin-1-rich granule membrane
R	1902600	biological_process	proton transmembrane transport
S	0005515	molecular_function	protein binding
S	0005765	cellular_component	lysosomal membrane
S	0006811	biological_process	monoatomic ion transport
S	0007035	biological_process	vacuolar acidification
S	0010008	cellular_component	endosome membrane
S	0016020	cellular_component	membrane
S	0016241	biological_process	regulation of macroautophagy
S	0030670	cellular_component	phagocytic vesicle membrane
S	0033179	cellular_component	proton-transporting V-type ATPase, V0 domain
S	0042625	molecular_function	ATPase-coupled ion transmembrane transporter activity
S	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
S	0055085	biological_process	transmembrane transport
S	1902600	biological_process	proton transmembrane transport
T	0000139	cellular_component	Golgi membrane
T	0000220	cellular_component	vacuolar proton-transporting V-type ATPase, V0 domain
T	0004518	molecular_function	nuclease activity
T	0004519	molecular_function	endonuclease activity
T	0004521	molecular_function	RNA endonuclease activity
T	0005515	molecular_function	protein binding
T	0005765	cellular_component	lysosomal membrane
T	0005886	cellular_component	plasma membrane
T	0006811	biological_process	monoatomic ion transport
T	0006897	biological_process	endocytosis
T	0006898	biological_process	receptor-mediated endocytosis
T	0007035	biological_process	vacuolar acidification
T	0007042	biological_process	lysosomal lumen acidification
T	0010008	cellular_component	endosome membrane
T	0012505	cellular_component	endomembrane system
T	0016020	cellular_component	membrane
T	0016787	molecular_function	hydrolase activity
T	0019065	biological_process	receptor-mediated endocytosis of virus by host cell
T	0030665	cellular_component	clathrin-coated vesicle membrane
T	0031410	cellular_component	cytoplasmic vesicle
T	0033176	cellular_component	proton-transporting V-type ATPase complex
T	0048388	biological_process	endosomal lumen acidification
T	0051452	biological_process	intracellular pH reduction
T	0061795	biological_process	Golgi lumen acidification
T	0090304	biological_process	nucleic acid metabolic process
T	1902600	biological_process	proton transmembrane transport
V	0016020	cellular_component	membrane
V	0038023	molecular_function	signaling receptor activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	285
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
V	ASN17-GLU302
4	MET1-TYR10
4	ALA77-GLN92
4	SER153-LYS155
5	MET1-TYR10
5	ALA77-GLN92
5	SER153-LYS155
6	MET1-TYR10
6	ALA77-GLN92
6	SER153-LYS155
7	MET1-TYR10
T	VAL104-CYS124
7	ALA77-GLN92
7	SER153-LYS155
8	MET1-TYR10
8	ALA77-GLN92
8	SER153-LYS155
9	MET1-TYR10
9	ALA77-GLN92
9	SER153-LYS155
R	SER555-PHE572
R	ARG659-THR724
R	PHE810-GLU837
2	SER153-LYS155
3	MET1-TYR10
3	ALA77-GLN92
3	SER153-LYS155

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
V	TYR303-ILE323
3	ILE56-ILE76
3	LEU93-GLY114
3	ILE132-LEU152
4	ALA11-GLY33
4	ILE56-ILE76
4	LEU93-GLY114
4	ILE132-LEU152
5	ALA11-GLY33
5	ILE56-ILE76
5	LEU93-GLY114
S	VAL36-ILE56
5	ILE132-LEU152
6	ALA11-GLY33
6	ILE56-ILE76
6	LEU93-GLY114
6	ILE132-LEU152
7	ALA11-GLY33
7	ILE56-ILE76
7	LEU93-GLY114
7	ILE132-LEU152
8	ALA11-GLY33
R	THR442-SER471
8	ILE56-ILE76
8	LEU93-GLY114
8	ILE132-LEU152
9	ALA11-GLY33
9	ILE56-ILE76
9	LEU93-GLY114
9	ILE132-LEU152
R	PHE535-LEU554
R	ILE573-LYS593
R	LEU639-LEU658
R	ILE725-ALA749
R	GLY771-GLU809
3	ALA11-GLY33

---

site_id	SWS_FT_FI3
Number of Residues	26
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
V	THR324-ASP350
5	ASP115-MET131
6	THR34-SER55
6	ASP115-MET131
7	THR34-SER55
7	ASP115-MET131
8	THR34-SER55
8	ASP115-MET131
9	THR34-SER55
9	ASP115-MET131
R	LEU472-SER534
R	TRP594-PHE638
R	GLN750-ALA770
3	THR34-SER55
3	ASP115-MET131
4	THR34-SER55
4	ASP115-MET131
5	THR34-SER55

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	SITE: Cleavage; by furin-like protease => ECO:0000305|PubMed:29127204

Chain	Residue	Details
V	ARG275
V	THR277
3	GLU139
4	GLU139
5	GLU139
6	GLU139
7	GLU139
8	GLU139
9	GLU139

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
U	SER465

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
U	ASN170

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:33065002, ECO:0007744|PDB:6WLW, ECO:0007744|PDB:6WM2, ECO:0007744|PDB:6WM3, ECO:0007744|PDB:6WM4

Chain	Residue	Details
U	ASN261
U	ASN273

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:33065002, ECO:0007744|PDB:6WM3, ECO:0007744|PDB:6WM4

Chain	Residue	Details
U	ASN296

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33065002, ECO:0007744|PDB:6WLW, ECO:0007744|PDB:6WM2, ECO:0007744|PDB:6WM3, ECO:0007744|PDB:6WM4

Chain	Residue	Details
U	ASN303
U	ASN350

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33065002, ECO:0007744|PDB:6WM3, ECO:0007744|PDB:6WM4

Chain	Residue	Details
U	ASN357

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