6V5C
Human Drosha and DGCR8 in complex with Primary MicroRNA (MP/RNA complex) - partially docked state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Ribonuclease 3 | polymer | 1016 | 118377.7 | 1 | UniProt (Q9NRR4) Pfam (PF14622) Pfam (PF00636) Pfam (PF00035) In PDB | Homo sapiens (Human) | Protein Drosha,Ribonuclease III,RNase III,p241 |
| 2 | C, B | Microprocessor complex subunit DGCR8 | polymer | 532 | 60550.6 | 2 | UniProt (Q8WYQ5) Pfam (PF00035) In PDB | Homo sapiens (Human) | DiGeorge syndrome critical region 8 |
| 3 | D | Pri-miR-16-2 (66-MER) | polymer | 105 | 33646.9 | 1 | GenBank (21206011) | Homo sapiens |
Sequence modifications
A: 353 - 1365 (UniProt: Q9NRR4)
C, B: 223 - 751 (UniProt: Q8WYQ5)
| PDB | External Database | Details |
|---|---|---|
| Gly 350 | - | expression tag |
| Ser 351 | - | expression tag |
| Gly 352 | - | expression tag |
| Gln 1045 | Glu 1045 | engineered mutation |
| Gln 1222 | Glu 1222 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 220 | - | expression tag |
| Ser 221 | - | expression tag |
| Gly 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 273125.9 | |
| All* | Total formula weight | 273125.9 |
