6V5C
Human Drosha and DGCR8 in complex with Primary MicroRNA (MP/RNA complex) - partially docked state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004525 | molecular_function | ribonuclease III activity |
| A | 0006364 | biological_process | rRNA processing |
| A | 0006396 | biological_process | RNA processing |
| A | 0031054 | biological_process | pre-miRNA processing |
| B | 0003723 | molecular_function | RNA binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0031053 | biological_process | primary miRNA processing |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0070877 | cellular_component | microprocessor complex |
| C | 0003723 | molecular_function | RNA binding |
| C | 0020037 | molecular_function | heme binding |
| C | 0031053 | biological_process | primary miRNA processing |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0070877 | cellular_component | microprocessor complex |
Functional Information from PROSITE/UniProt
| site_id | PS00517 |
| Number of Residues | 9 |
| Details | RNASE_3_1 Ribonuclease III family signature. ERLEFLGDA |
| Chain | Residue | Details |
| A | GLU966-ALA974 | |
| A | GLN1144-SER1152 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: axial binding residue => ECO:0000305|PubMed:17159994 |
| Chain | Residue | Details |
| A | HIS609 | |
| A | CYS676 | |
| A | HIS680 | |
| A | HIS1026 | |
| C | CYS352 | |
| B | CYS352 | |
| A | HIS549 | |
| A | CYS561 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| B | SER271 | |
| A | GLU1147 | |
| A | ASP1219 | |
| C | SER271 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER275 | |
| B | SER275 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9EQM6 |
| Chain | Residue | Details |
| C | THR279 | |
| B | THR279 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21406692 |
| Chain | Residue | Details |
| B | THR371 | |
| C | THR371 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER373 | |
| B | SER373 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| C | SER377 | |
| B | SER377 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS424 | |
| B | LYS424 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297 |
| Chain | Residue | Details |
| C | LYS707 | |
| B | LYS707 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS500 | |
| B | LYS500 |
