6UTJ

Allosteric couple between alpha rings of the 20S proteasome. 20S proteasome singly capped by PA26/E102A, C-terminus replaced by PAN C-terminus

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Proteasome subunit alpha	polymer	227	25125.6	7	UniProt (P25156) Pfam (PF10584) Pfam (PF00227) In PDB	Thermoplasma acidophilum	20S proteasome alpha subunit,Proteasome core protein PsmA
2	O, P, Q, R, S...	Proteasome activator protein PA26	polymer	229	25088.6	7	UniProt (Q38BM8) Pfam (PF02252) In PDB	Trypanosoma brucei brucei
3	Z, M, 1, N, 2...	Proteasome subunit beta	polymer	203	22294.8	14	UniProt (P28061) Pfam (PF00227) In PDB	Thermoplasma acidophilum	20S proteasome subunit B, 20S proteasome beta subunit, Proteasome core protein PsmB
4	a, b, c, d, e...	Proteasome subunit alpha	polymer	226	24996.4	7	UniProt (P25156) Pfam (PF10584) Pfam (PF00227) In PDB	Thermoplasma acidophilum	20S proteasome alpha subunit,Proteasome core protein PsmA

Sequence modifications

O, P, Q, R, S, T, U: 4 - 223 (UniProt: Q38BM8)

PDB	External Database	Details
Gly 48	Ala 48	conflict
Ala 102	Glu 102	conflict
Gly 224	-	expression tag
Gly 225	-	expression tag
His 226	-	expression tag
Leu 227	-	expression tag
Asp 228	-	expression tag
Val 229	-	expression tag
Leu 230	-	expression tag
Tyr 231	-	expression tag
Arg 232	-	expression tag

a, b, c, d, e, f, g: 8 - 233 (UniProt: P25156)

PDB	External Database	Details
Ala 66	Lys 66	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	35
	Total formula weight	838602.4
All*	Total formula weight	838602.4

*Water molecules are not included.