6UTJ

Allosteric couple between alpha rings of the 20S proteasome. 20S proteasome singly capped by PA26/E102A, C-terminus replaced by PAN C-terminus

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005737	cellular_component	cytoplasm
1	0005839	cellular_component	proteasome core complex
1	0006508	biological_process	proteolysis
1	0010498	biological_process	proteasomal protein catabolic process
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0051603	biological_process	proteolysis involved in protein catabolic process
2	0000502	cellular_component	proteasome complex
2	0004175	molecular_function	endopeptidase activity
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005737	cellular_component	cytoplasm
2	0005839	cellular_component	proteasome core complex
2	0006508	biological_process	proteolysis
2	0010498	biological_process	proteasomal protein catabolic process
2	0019774	cellular_component	proteasome core complex, beta-subunit complex
2	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0004175	molecular_function	endopeptidase activity
A	0004298	molecular_function	threonine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010498	biological_process	proteasomal protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0019774	cellular_component	proteasome core complex, beta-subunit complex
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0004175	molecular_function	endopeptidase activity
B	0004298	molecular_function	threonine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010498	biological_process	proteasomal protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0019774	cellular_component	proteasome core complex, beta-subunit complex
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0004175	molecular_function	endopeptidase activity
C	0004298	molecular_function	threonine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010498	biological_process	proteasomal protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0019774	cellular_component	proteasome core complex, beta-subunit complex
C	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0004175	molecular_function	endopeptidase activity
D	0004298	molecular_function	threonine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010498	biological_process	proteasomal protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0019774	cellular_component	proteasome core complex, beta-subunit complex
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0004175	molecular_function	endopeptidase activity
E	0004298	molecular_function	threonine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010498	biological_process	proteasomal protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0019774	cellular_component	proteasome core complex, beta-subunit complex
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0004175	molecular_function	endopeptidase activity
F	0004298	molecular_function	threonine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010498	biological_process	proteasomal protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0019774	cellular_component	proteasome core complex, beta-subunit complex
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0000502	cellular_component	proteasome complex
G	0004175	molecular_function	endopeptidase activity
G	0004298	molecular_function	threonine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0010498	biological_process	proteasomal protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0019774	cellular_component	proteasome core complex, beta-subunit complex
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0000502	cellular_component	proteasome complex
H	0004175	molecular_function	endopeptidase activity
H	0004298	molecular_function	threonine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0005839	cellular_component	proteasome core complex
H	0006508	biological_process	proteolysis
H	0010498	biological_process	proteasomal protein catabolic process
H	0019774	cellular_component	proteasome core complex, beta-subunit complex
H	0051603	biological_process	proteolysis involved in protein catabolic process
I	0000502	cellular_component	proteasome complex
I	0004175	molecular_function	endopeptidase activity
I	0004298	molecular_function	threonine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0005839	cellular_component	proteasome core complex
I	0006508	biological_process	proteolysis
I	0010498	biological_process	proteasomal protein catabolic process
I	0019774	cellular_component	proteasome core complex, beta-subunit complex
I	0051603	biological_process	proteolysis involved in protein catabolic process
J	0000502	cellular_component	proteasome complex
J	0004175	molecular_function	endopeptidase activity
J	0004298	molecular_function	threonine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0005839	cellular_component	proteasome core complex
J	0006508	biological_process	proteolysis
J	0010498	biological_process	proteasomal protein catabolic process
J	0019774	cellular_component	proteasome core complex, beta-subunit complex
J	0051603	biological_process	proteolysis involved in protein catabolic process
K	0000502	cellular_component	proteasome complex
K	0004175	molecular_function	endopeptidase activity
K	0004298	molecular_function	threonine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0005839	cellular_component	proteasome core complex
K	0006508	biological_process	proteolysis
K	0010498	biological_process	proteasomal protein catabolic process
K	0019774	cellular_component	proteasome core complex, beta-subunit complex
K	0051603	biological_process	proteolysis involved in protein catabolic process
L	0000502	cellular_component	proteasome complex
L	0004175	molecular_function	endopeptidase activity
L	0004298	molecular_function	threonine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0005839	cellular_component	proteasome core complex
L	0006508	biological_process	proteolysis
L	0010498	biological_process	proteasomal protein catabolic process
L	0019774	cellular_component	proteasome core complex, beta-subunit complex
L	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0004175	molecular_function	endopeptidase activity
M	0004298	molecular_function	threonine-type endopeptidase activity
M	0005737	cellular_component	cytoplasm
M	0005839	cellular_component	proteasome core complex
M	0006508	biological_process	proteolysis
M	0010498	biological_process	proteasomal protein catabolic process
M	0019774	cellular_component	proteasome core complex, beta-subunit complex
M	0051603	biological_process	proteolysis involved in protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0004175	molecular_function	endopeptidase activity
N	0004298	molecular_function	threonine-type endopeptidase activity
N	0005737	cellular_component	cytoplasm
N	0005839	cellular_component	proteasome core complex
N	0006508	biological_process	proteolysis
N	0010498	biological_process	proteasomal protein catabolic process
N	0019774	cellular_component	proteasome core complex, beta-subunit complex
N	0051603	biological_process	proteolysis involved in protein catabolic process
O	0000502	cellular_component	proteasome complex
O	0006508	biological_process	proteolysis
O	0008537	cellular_component	proteasome activator complex
O	0061136	biological_process	regulation of proteasomal protein catabolic process
P	0000502	cellular_component	proteasome complex
P	0006508	biological_process	proteolysis
P	0008537	cellular_component	proteasome activator complex
P	0061136	biological_process	regulation of proteasomal protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0006508	biological_process	proteolysis
Q	0008537	cellular_component	proteasome activator complex
Q	0061136	biological_process	regulation of proteasomal protein catabolic process
R	0000502	cellular_component	proteasome complex
R	0006508	biological_process	proteolysis
R	0008537	cellular_component	proteasome activator complex
R	0061136	biological_process	regulation of proteasomal protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0006508	biological_process	proteolysis
S	0008537	cellular_component	proteasome activator complex
S	0061136	biological_process	regulation of proteasomal protein catabolic process
T	0000502	cellular_component	proteasome complex
T	0006508	biological_process	proteolysis
T	0008537	cellular_component	proteasome activator complex
T	0061136	biological_process	regulation of proteasomal protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0006508	biological_process	proteolysis
U	0008537	cellular_component	proteasome activator complex
U	0061136	biological_process	regulation of proteasomal protein catabolic process
V	0000502	cellular_component	proteasome complex
V	0004175	molecular_function	endopeptidase activity
V	0004298	molecular_function	threonine-type endopeptidase activity
V	0005737	cellular_component	cytoplasm
V	0005839	cellular_component	proteasome core complex
V	0006508	biological_process	proteolysis
V	0010498	biological_process	proteasomal protein catabolic process
V	0019774	cellular_component	proteasome core complex, beta-subunit complex
V	0051603	biological_process	proteolysis involved in protein catabolic process
W	0000502	cellular_component	proteasome complex
W	0004175	molecular_function	endopeptidase activity
W	0004298	molecular_function	threonine-type endopeptidase activity
W	0005737	cellular_component	cytoplasm
W	0005839	cellular_component	proteasome core complex
W	0006508	biological_process	proteolysis
W	0010498	biological_process	proteasomal protein catabolic process
W	0019774	cellular_component	proteasome core complex, beta-subunit complex
W	0051603	biological_process	proteolysis involved in protein catabolic process
X	0000502	cellular_component	proteasome complex
X	0004175	molecular_function	endopeptidase activity
X	0004298	molecular_function	threonine-type endopeptidase activity
X	0005737	cellular_component	cytoplasm
X	0005839	cellular_component	proteasome core complex
X	0006508	biological_process	proteolysis
X	0010498	biological_process	proteasomal protein catabolic process
X	0019774	cellular_component	proteasome core complex, beta-subunit complex
X	0051603	biological_process	proteolysis involved in protein catabolic process
Y	0000502	cellular_component	proteasome complex
Y	0004175	molecular_function	endopeptidase activity
Y	0004298	molecular_function	threonine-type endopeptidase activity
Y	0005737	cellular_component	cytoplasm
Y	0005839	cellular_component	proteasome core complex
Y	0006508	biological_process	proteolysis
Y	0010498	biological_process	proteasomal protein catabolic process
Y	0019774	cellular_component	proteasome core complex, beta-subunit complex
Y	0051603	biological_process	proteolysis involved in protein catabolic process
Z	0000502	cellular_component	proteasome complex
Z	0004175	molecular_function	endopeptidase activity
Z	0004298	molecular_function	threonine-type endopeptidase activity
Z	0005737	cellular_component	cytoplasm
Z	0005839	cellular_component	proteasome core complex
Z	0006508	biological_process	proteolysis
Z	0010498	biological_process	proteasomal protein catabolic process
Z	0019774	cellular_component	proteasome core complex, beta-subunit complex
Z	0051603	biological_process	proteolysis involved in protein catabolic process
a	0000502	cellular_component	proteasome complex
a	0004175	molecular_function	endopeptidase activity
a	0004298	molecular_function	threonine-type endopeptidase activity
a	0005737	cellular_component	cytoplasm
a	0005829	cellular_component	cytosol
a	0005839	cellular_component	proteasome core complex
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0010498	biological_process	proteasomal protein catabolic process
a	0019773	cellular_component	proteasome core complex, alpha-subunit complex
a	0019774	cellular_component	proteasome core complex, beta-subunit complex
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0004175	molecular_function	endopeptidase activity
b	0004298	molecular_function	threonine-type endopeptidase activity
b	0005737	cellular_component	cytoplasm
b	0005829	cellular_component	cytosol
b	0005839	cellular_component	proteasome core complex
b	0006511	biological_process	ubiquitin-dependent protein catabolic process
b	0010498	biological_process	proteasomal protein catabolic process
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
b	0019774	cellular_component	proteasome core complex, beta-subunit complex
b	0051603	biological_process	proteolysis involved in protein catabolic process
c	0000502	cellular_component	proteasome complex
c	0004175	molecular_function	endopeptidase activity
c	0004298	molecular_function	threonine-type endopeptidase activity
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005839	cellular_component	proteasome core complex
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0010498	biological_process	proteasomal protein catabolic process
c	0019773	cellular_component	proteasome core complex, alpha-subunit complex
c	0019774	cellular_component	proteasome core complex, beta-subunit complex
c	0051603	biological_process	proteolysis involved in protein catabolic process
d	0000502	cellular_component	proteasome complex
d	0004175	molecular_function	endopeptidase activity
d	0004298	molecular_function	threonine-type endopeptidase activity
d	0005737	cellular_component	cytoplasm
d	0005829	cellular_component	cytosol
d	0005839	cellular_component	proteasome core complex
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0010498	biological_process	proteasomal protein catabolic process
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0019774	cellular_component	proteasome core complex, beta-subunit complex
d	0051603	biological_process	proteolysis involved in protein catabolic process
e	0000502	cellular_component	proteasome complex
e	0004175	molecular_function	endopeptidase activity
e	0004298	molecular_function	threonine-type endopeptidase activity
e	0005737	cellular_component	cytoplasm
e	0005829	cellular_component	cytosol
e	0005839	cellular_component	proteasome core complex
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0010498	biological_process	proteasomal protein catabolic process
e	0019773	cellular_component	proteasome core complex, alpha-subunit complex
e	0019774	cellular_component	proteasome core complex, beta-subunit complex
e	0051603	biological_process	proteolysis involved in protein catabolic process
f	0000502	cellular_component	proteasome complex
f	0004175	molecular_function	endopeptidase activity
f	0004298	molecular_function	threonine-type endopeptidase activity
f	0005737	cellular_component	cytoplasm
f	0005829	cellular_component	cytosol
f	0005839	cellular_component	proteasome core complex
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0010498	biological_process	proteasomal protein catabolic process
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0019774	cellular_component	proteasome core complex, beta-subunit complex
f	0051603	biological_process	proteolysis involved in protein catabolic process
g	0000502	cellular_component	proteasome complex
g	0004175	molecular_function	endopeptidase activity
g	0004298	molecular_function	threonine-type endopeptidase activity
g	0005737	cellular_component	cytoplasm
g	0005829	cellular_component	cytosol
g	0005839	cellular_component	proteasome core complex
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0010498	biological_process	proteasomal protein catabolic process
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0019774	cellular_component	proteasome core complex, beta-subunit complex
g	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PROSITE/UniProt

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGRlfQVEYAreA

Chain	Residue	Details
a	TYR8-ALA30
A	TYR8-ALA30

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGItLkdAVIMATErrvtmenfimhkngk.KlfqidtytgmtiaGlvGD

Chain	Residue	Details
Y	VAL4-ASP51

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_02113, ECO:0000269|PubMed:7725107

Chain	Residue	Details
Z	THR1
M	THR1
1	THR1
N	THR1
2	THR1
H	THR1
V	THR1
I	THR1
W	THR1
J	THR1
X	THR1
K	THR1
Y	THR1
L	THR1

---