6U8Q
CryoEM structure of HIV-1 cleaved synaptic complex (CSC) intasome
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, I... | Integrase | polymer | 364 | 39898.4 | 12 | UniProt (Q76353) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552) UniProt (by SIFTS) (P12497) In PDB | Human immunodeficiency virus 1 (HIV-1) | P5 integrase |
| 2 | E, G | DNA (27-MER) | polymer | 27 | 8188.3 | 2 | Escherichia coli | ||
| 3 | F, H | DNA (25-MER) | polymer | 25 | 7773.0 | 2 | Escherichia coli | ||
| 4 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | A, C | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | non-polymer | 419.4 | 2 | Chemie (DLU) |
Sequence modifications
A, B, C, D, I, J, K, L, M, N, O, P: 1 - 288 (UniProt: Q76353)
| PDB | External Database | Details |
|---|---|---|
| Gly -75 | - | expression tag |
| Ser -74 | - | expression tag |
| His -73 | - | expression tag |
| Met -72 | - | expression tag |
| Pro -71 | - | expression tag |
| Lys -70 | - | expression tag |
| Arg -69 | - | expression tag |
| Gly -68 | - | expression tag |
| Arg -67 | - | expression tag |
| Pro -66 | - | expression tag |
| Ala -65 | - | expression tag |
| Ala -64 | - | expression tag |
| Thr -63 | - | expression tag |
| Glu -62 | - | expression tag |
| Val -61 | - | expression tag |
| Lys -60 | - | expression tag |
| Ile -59 | - | expression tag |
| Pro -58 | - | expression tag |
| Lys -57 | - | expression tag |
| Pro -56 | - | expression tag |
| Arg -55 | - | expression tag |
| Gly -54 | - | expression tag |
| Arg -53 | - | expression tag |
| Pro -52 | - | expression tag |
| Pro -51 | - | expression tag |
| Leu -50 | - | expression tag |
| Pro -49 | - | expression tag |
| Ala -48 | - | expression tag |
| Gly -47 | - | expression tag |
| Thr -46 | - | expression tag |
| Asn -45 | - | expression tag |
| Ser -44 | - | expression tag |
| Lys -43 | - | expression tag |
| Gly -42 | - | expression tag |
| Pro -41 | - | expression tag |
| Pro -40 | - | expression tag |
| Asp -39 | - | expression tag |
| Phe -38 | - | expression tag |
| Ser -37 | - | expression tag |
| Ser -36 | - | expression tag |
| Asp -35 | - | expression tag |
| Glu -34 | - | expression tag |
| Glu -33 | - | expression tag |
| Arg -32 | - | expression tag |
| Glu -31 | - | expression tag |
| Pro -30 | - | expression tag |
| Thr -29 | - | expression tag |
| Pro -28 | - | expression tag |
| Val -27 | - | expression tag |
| Leu -26 | - | expression tag |
| Gly -25 | - | expression tag |
| Ser -24 | - | expression tag |
| Gly -23 | - | expression tag |
| Ala -22 | - | expression tag |
| Ala -21 | - | expression tag |
| Ala -20 | - | expression tag |
| Ala -19 | - | expression tag |
| Gly -18 | - | expression tag |
| Gln -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Arg -15 | - | expression tag |
| Ala -14 | - | expression tag |
| Ala -13 | - | expression tag |
| Val -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Arg -10 | - | expression tag |
| Lys -9 | - | expression tag |
| Ala -8 | - | expression tag |
| Thr -7 | - | expression tag |
| Lys -6 | - | expression tag |
| Lys -5 | - | expression tag |
| Thr -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 510702.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 936.0 | |
| All* | Total formula weight | 511638.8 |
