6U8Q

CryoEM structure of HIV-1 cleaved synaptic complex (CSC) intasome

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0008270	molecular_function	zinc ion binding
A	0015074	biological_process	DNA integration
B	0003676	molecular_function	nucleic acid binding
B	0008270	molecular_function	zinc ion binding
B	0015074	biological_process	DNA integration
C	0003676	molecular_function	nucleic acid binding
C	0008270	molecular_function	zinc ion binding
C	0015074	biological_process	DNA integration
D	0003676	molecular_function	nucleic acid binding
D	0008270	molecular_function	zinc ion binding
D	0015074	biological_process	DNA integration
I	0003676	molecular_function	nucleic acid binding
I	0008270	molecular_function	zinc ion binding
I	0015074	biological_process	DNA integration
J	0003676	molecular_function	nucleic acid binding
J	0008270	molecular_function	zinc ion binding
J	0015074	biological_process	DNA integration
K	0003676	molecular_function	nucleic acid binding
K	0008270	molecular_function	zinc ion binding
K	0015074	biological_process	DNA integration
L	0003676	molecular_function	nucleic acid binding
L	0008270	molecular_function	zinc ion binding
L	0015074	biological_process	DNA integration
M	0003676	molecular_function	nucleic acid binding
M	0008270	molecular_function	zinc ion binding
M	0015074	biological_process	DNA integration
N	0003676	molecular_function	nucleic acid binding
N	0008270	molecular_function	zinc ion binding
N	0015074	biological_process	DNA integration
O	0003676	molecular_function	nucleic acid binding
O	0008270	molecular_function	zinc ion binding
O	0015074	biological_process	DNA integration
P	0003676	molecular_function	nucleic acid binding
P	0008270	molecular_function	zinc ion binding
P	0015074	biological_process	DNA integration

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 301

Chain	Residue
A	ASP64
A	ASP116
A	MG302
A	DLU303

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 302

Chain	Residue
A	ASP64
A	GLU152
A	MG301
A	DLU303

---

site_id	AC3
Number of Residues	9
Details	binding site for residue DLU A 303

Chain	Residue
A	ASP116
A	GLN146
A	GLU152
A	MG301
A	MG302
G	DG18
H	DC20
H	DA21
A	ASP64

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG C 301

Chain	Residue
C	ASP64
C	ASP116
C	MG302
C	DLU303

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MG C 302

Chain	Residue
C	ASP64
C	GLU152
C	MG301
C	DLU303

---

site_id	AC6
Number of Residues	8
Details	binding site for residue DLU C 303

Chain	Residue
C	ASP116
C	GLN146
C	GLU152
C	MG301
C	MG302
E	DG18
F	DC20
F	DA21

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	492
Details	ZN_FING: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00450

Chain	Residue	Details
A	ASP3-GLN44
B	ASP3-GLN44
C	ASP3-GLN44
D	ASP3-GLN44
I	ASP3-GLN44
J	ASP3-GLN44
K	ASP3-GLN44
L	ASP3-GLN44
M	ASP3-GLN44
N	ASP3-GLN44
O	ASP3-GLN44
P	ASP3-GLN44

---

site_id	SWS_FT_FI2
Number of Residues	564
Details	DNA_BIND: Integrase-type => ECO:0000255|PROSITE-ProRule:PRU00506

Chain	Residue	Details
A	PHE223-ASP270
B	PHE223-ASP270
C	PHE223-ASP270
D	PHE223-ASP270
I	PHE223-ASP270
J	PHE223-ASP270
K	PHE223-ASP270
L	PHE223-ASP270
M	PHE223-ASP270
N	PHE223-ASP270
O	PHE223-ASP270
P	PHE223-ASP270

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00450

Chain	Residue	Details
A	HIS12
A	HIS16
A	CYS40
A	CYS43
B	HIS12
B	HIS16
B	CYS40
B	CYS43
C	HIS12
C	HIS16
C	CYS40
C	CYS43
D	HIS12
D	HIS16
D	CYS40
D	CYS43
I	HIS12
I	HIS16
I	CYS40
I	CYS43
J	HIS12
J	HIS16
J	CYS40
J	CYS43
K	HIS12
K	HIS16
K	CYS40
K	CYS43
L	HIS12
L	HIS16
L	CYS40
L	CYS43
M	HIS12
M	HIS16
M	CYS40
M	CYS43
N	HIS12
N	HIS16
N	CYS40
N	CYS43
O	HIS12
O	HIS16
O	CYS40
O	CYS43
P	HIS12
P	HIS16
P	CYS40
P	CYS43

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
A	ASP64
A	ASP116
B	ASP64
B	ASP116
C	ASP64
C	ASP116
D	ASP64
D	ASP116
I	ASP64
I	ASP116
J	ASP64
J	ASP116
K	ASP64
K	ASP116
L	ASP64
L	ASP116
M	ASP64
M	ASP116
N	ASP64
N	ASP116
O	ASP64
O	ASP116
P	ASP64
P	ASP116

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P04585

Chain	Residue	Details
A	GLU152
B	GLU152
C	GLU152
D	GLU152
I	GLU152
J	GLU152
K	GLU152
L	GLU152
M	GLU152
N	GLU152
O	GLU152
P	GLU152

---