6RPJ

A Non-blocking anti-CTLA-4 Nanobody complexed with CTLA-4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G	Cytotoxic T-lymphocyte protein 4	polymer	129	13893.7	4	UniProt (P16410) Pfam (PF07686) In PDB	Homo sapiens (Human)	Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4
2	B, D, F, H	A non-blocking CTLA-4 nanobody	polymer	142	15203.6	4		Camelus bactrianus (Bactrian Camel)
3	I, J, K	alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		367.3	3	In PDB GlyTouCan (G86851RC)
4	C, E, G	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	E, G	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
6		water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, C, E, G: 2 - 121 (UniProt: P16410)

PDB	External Database	Details
Gly 122	-	expression tag
Gly 123	-	expression tag
Ser 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag
His 130	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	116389.3
Branched	Number of molecules	3
	Total formula weight	1102.0
Non-Polymers*	Number of molecules	6
	Total formula weight	930.8
All*	Total formula weight	118422.2

*Water molecules are not included.