6PAI
Structure of the human DDB1-DDA1-DCAF15 E3 ubiquitin ligase bound to RBM39 and sulfonamide E7820
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | DNA damage-binding protein 1 | polymer | 1140 | 127097.5 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) In PDB | Homo sapiens (Human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 2 | C | DDB1- and CUL4-associated factor 15 | polymer | 498 | 56414.9 | 1 | UniProt (Q66K64) Pfam (PF14939) In PDB | Homo sapiens (Human) | |
| 3 | D | RNA-binding protein 39 | polymer | 109 | 12098.6 | 1 | UniProt (Q7Z3L0) Pfam (PF00076) UniProt (by SIFTS) (Q14498) In PDB | Homo sapiens (Human) | |
| 4 | E | DET1- and DDB1-associated protein 1 | polymer | 102 | 11855.3 | 1 | UniProt (Q9BW61) Pfam (PF10172) In PDB | Homo sapiens (Human) | Placenta cross-immune reaction antigen 1,PCIA-1 |
| 5 | A | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 2 | Chemie (EPE) | |||
| 6 | C | 3-cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzene-1-sulfonamide | non-polymer | 336.4 | 1 | Chemie (O6M) | |||
| 7 | C | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 8 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
C: 2 - 383 (UniProt: Q66K64)
C: 384 - 600 (UniProt: Q66K64)
D: 235 - 331 (UniProt: Q7Z3L0)
| PDB | External Database | Details |
|---|---|---|
| Met -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
D: 235 - 331 (UniProt: Q7Z3L0)
| PDB | External Database | Details |
|---|---|---|
| Gly 231 | - | expression tag |
| Ser 232 | - | expression tag |
| His 233 | - | expression tag |
| Met 234 | - | expression tag |
| Asp 332 | - | expression tag |
| Tyr 333 | - | expression tag |
| Lys 334 | - | expression tag |
| Asp 335 | - | expression tag |
| Asp 336 | - | expression tag |
| Asp 337 | - | expression tag |
| Asp 338 | - | expression tag |
| Lys 339 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 207466.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 878.4 | |
| All* | Total formula weight | 208344.6 |
