6O5I
Menin in complex with MI-3454
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Menin | polymer | 489 | 54600.2 | 1 | UniProt (O00255) Pfam (PF05053) In PDB | Homo sapiens (Human) | |
| 2 | A | ~{N}-[3-[[2-cyano-4-methyl-5-[[4-[[2-(methylamino)-6-[2,2,2-tris(fluoranyl)ethyl]thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]indol-1-yl]methyl]-1-bicyclo[1.1.1]pentanyl]methanamide | non-polymer | 636.7 | 1 | Chemie (LMY) | |||
| 3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 4 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 6 | water | water | 18.0 | 871 | Chemie (HOH) |
Sequence modifications
A: 1 - 53 (UniProt: O00255)
A: 74 - 386 (UniProt: O00255)
A: 399 - 459 (UniProt: O00255)
A: 537 - 593 (UniProt: O00255)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
A: 399 - 459 (UniProt: O00255)
A: 537 - 593 (UniProt: O00255)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54600.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1431.7 | |
| All* | Total formula weight | 56031.9 |
