6NZU
Structure of the human frataxin-bound iron-sulfur cluster assembly complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, E | Cysteine desulfurase, mitochondrial | polymer | 403 | 44850.4 | 2 | UniProt (Q9Y697) Pfam (PF00266) In PDB | Homo sapiens (Human) | |
2 | B, F | LYR motif-containing protein 4 | polymer | 92 | 10850.6 | 2 | UniProt (Q9HD34) Pfam (PF05347) In PDB | Homo sapiens (Human) | |
3 | C, G | Acyl carrier protein | polymer | 74 | 8251.1 | 2 | UniProt (A0A437HBF4) In PDB | Escherichia coli | ACP |
4 | D, H | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial | polymer | 124 | 13412.6 | 2 | UniProt (Q9H1K1) Pfam (PF01592) In PDB | Homo sapiens (Human) | NifU-like N-terminal domain-containing protein, NifU-like protein |
5 | I, J | Frataxin, mitochondrial | polymer | 132 | 14501.0 | 2 | UniProt (Q16595) Pfam (PF01491) In PDB | Homo sapiens (Human) | Friedreich ataxia protein, Fxn |
6 | A, E | PYRIDOXAL-5'-PHOSPHATE | non-polymer | 247.1 | 2 | Chemie (PLP) | |||
7 | C, G | S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate | non-polymer | 540.7 | 2 | Chemie (8Q1) | |||
8 | D, H | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) |
Sequence modifications
A, E: 56 - 457 (UniProt: Q9Y697)
B, F: 1 - 91 (UniProt: Q9HD34)
D, H: 35 - 157 (UniProt: Q9H1K1)
I, J: 81 - 210 (UniProt: Q16595)
PDB | External Database | Details |
---|---|---|
Met 55 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Ser 0 | - | expression tag |
Ala 11 | Ser 11 | conflict |
PDB | External Database | Details |
---|---|---|
Met 34 | - | initiating methionine |
PDB | External Database | Details |
---|---|---|
Ser 79 | - | expression tag |
Met 80 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 183731.1 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1706.4 | |
All* | Total formula weight | 185437.5 |