6NZU
Structure of the human frataxin-bound iron-sulfur cluster assembly complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0031071 | molecular_function | cysteine desulfurase activity |
A | 0044571 | biological_process | [2Fe-2S] cluster assembly |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0016226 | biological_process | iron-sulfur cluster assembly |
B | 0016604 | cellular_component | nuclear body |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0044571 | biological_process | [2Fe-2S] cluster assembly |
B | 0044572 | biological_process | [4Fe-4S] cluster assembly |
B | 0099128 | cellular_component | mitochondrial [2Fe-2S] assembly complex |
B | 1990221 | cellular_component | L-cysteine desulfurase complex |
B | 1990229 | cellular_component | iron-sulfur cluster assembly complex |
C | 0006633 | biological_process | fatty acid biosynthetic process |
D | 0005506 | molecular_function | iron ion binding |
D | 0016226 | biological_process | iron-sulfur cluster assembly |
D | 0051536 | molecular_function | iron-sulfur cluster binding |
E | 0030170 | molecular_function | pyridoxal phosphate binding |
E | 0031071 | molecular_function | cysteine desulfurase activity |
E | 0044571 | biological_process | [2Fe-2S] cluster assembly |
F | 0005515 | molecular_function | protein binding |
F | 0005634 | cellular_component | nucleus |
F | 0005739 | cellular_component | mitochondrion |
F | 0005759 | cellular_component | mitochondrial matrix |
F | 0016226 | biological_process | iron-sulfur cluster assembly |
F | 0016604 | cellular_component | nuclear body |
F | 0042803 | molecular_function | protein homodimerization activity |
F | 0044571 | biological_process | [2Fe-2S] cluster assembly |
F | 0044572 | biological_process | [4Fe-4S] cluster assembly |
F | 0099128 | cellular_component | mitochondrial [2Fe-2S] assembly complex |
F | 1990221 | cellular_component | L-cysteine desulfurase complex |
F | 1990229 | cellular_component | iron-sulfur cluster assembly complex |
G | 0006633 | biological_process | fatty acid biosynthetic process |
H | 0005506 | molecular_function | iron ion binding |
H | 0016226 | biological_process | iron-sulfur cluster assembly |
H | 0051536 | molecular_function | iron-sulfur cluster binding |
I | 0004322 | molecular_function | ferroxidase activity |
I | 0005739 | cellular_component | mitochondrion |
I | 0006879 | biological_process | intracellular iron ion homeostasis |
I | 0008199 | molecular_function | ferric iron binding |
I | 0016226 | biological_process | iron-sulfur cluster assembly |
I | 0018283 | biological_process | iron incorporation into metallo-sulfur cluster |
J | 0004322 | molecular_function | ferroxidase activity |
J | 0005739 | cellular_component | mitochondrion |
J | 0006879 | biological_process | intracellular iron ion homeostasis |
J | 0008199 | molecular_function | ferric iron binding |
J | 0016226 | biological_process | iron-sulfur cluster assembly |
J | 0018283 | biological_process | iron incorporation into metallo-sulfur cluster |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue PLP A 501 |
Chain | Residue |
A | GLY126 |
A | ALA127 |
A | THR128 |
A | ASP232 |
A | GLN235 |
A | SER255 |
A | HIS257 |
A | LYS258 |
E | THR295 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue 8Q1 C 101 |
Chain | Residue |
B | ARG6 |
B | ALA39 |
B | PHE40 |
B | ASN43 |
B | LYS44 |
B | ASP62 |
C | SER37 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue ZN D 201 |
Chain | Residue |
D | ASP71 |
D | CYS95 |
D | CYS138 |
site_id | AC4 |
Number of Residues | 9 |
Details | binding site for residue PLP E 501 |
Chain | Residue |
A | THR295 |
E | GLY126 |
E | ALA127 |
E | THR128 |
E | ASP232 |
E | GLN235 |
E | SER255 |
E | HIS257 |
E | LYS258 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue ZN H 201 |
Chain | Residue |
H | ASP71 |
H | CYS95 |
H | CYS138 |
site_id | AC6 |
Number of Residues | 13 |
Details | binding site for Di-peptide 8Q1 G 101 and SER G 37 |
Chain | Residue |
E | PRO71 |
F | ARG6 |
F | ALA39 |
F | PHE40 |
F | ASN43 |
F | LYS44 |
F | VAL46 |
F | ASP62 |
G | ASP36 |
G | LEU38 |
G | ASP39 |
G | THR40 |
G | VAL41 |
Functional Information from PROSITE/UniProt
site_id | PS00012 |
Number of Residues | 16 |
Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL |
Chain | Residue | Details |
C | ASP32-LEU47 |
site_id | PS00595 |
Number of Residues | 20 |
Details | AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDLMsiSGHKiygpk.GvGaI |
Chain | Residue | Details |
A | ILE249-ILE268 |
site_id | PS01344 |
Number of Residues | 15 |
Details | FRATAXIN_1 Frataxin family signature. VINKQtPnkQIWlSS |
Chain | Residue | Details |
I | VAL144-SER158 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Cysteine persulfide intermediate => ECO:0000250|UniProtKB:Q9D7P6 |
Chain | Residue | Details |
D | CYS69 | |
H | CYS69 | |
F | ARG6 | |
F | LYS44 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Cysteine persulfide intermediate => ECO:0000250|UniProtKB:O29689 |
Chain | Residue | Details |
D | CYS138 | |
H | CYS138 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:31101807, ECO:0007744|PDB:6NZU |
Chain | Residue | Details |
D | ASP71 | |
D | CYS95 | |
D | CYS138 | |
H | ASP71 | |
H | CYS95 | |
H | CYS138 | |
E | SER255 | |
E | HIS257 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Mediates ISCU dimerization and de novo [2Fe-2S] cluster assembly => ECO:0000269|PubMed:34824239 |
Chain | Residue | Details |
D | TYR35 | |
H | TYR35 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Cysteine persulfide => ECO:0000250|UniProtKB:Q9D7P6 |
Chain | Residue | Details |
D | CYS69 | |
H | CYS69 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Cysteine persulfide => ECO:0000305|PubMed:24971490 |
Chain | Residue | Details |
D | CYS138 | |
H | CYS138 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Cysteine persulfide => ECO:0000305|PubMed:18650437, ECO:0000305|PubMed:23593335 |
Chain | Residue | Details |
A | CYS381 | |
E | CYS381 |