6HXH
Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... | ATP-citrate synthase,Human ATP citrate lyase | polymer | 1050 | 115880.5 | 8 | UniProt (P53396) Pfam (PF16114) Pfam (PF02629) Pfam (PF00549) Pfam (PF00285) In PDB | Homo sapiens (Human) | ATP-citrate (pro-S-)-lyase,ACL,Citrate cleavage enzyme |
| 2 | D, H, E, A, F... | MAGNESIUM ION | non-polymer | 24.3 | 16 | Chemie (MG) | |||
| 3 | D, E, A, F, B... | PHOSPHATE ION | non-polymer | 95.0 | 8 | Chemie (PO4) | |||
| 4 | H, D, E, A, F... | CITRATE ANION | non-polymer | 189.1 | 8 | Chemie (FLC) | |||
| 5 | H, D, E, A, F... | COENZYME A | non-polymer | 767.5 | 8 | Chemie (COA) | |||
| 6 | H, D, E, A, F... | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 8 | Chemie (ADP) | |||
| 7 | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 424 (UniProt: P53396)
A, B, C, D, E, F, G, H: 488 - 1110 (PDB: 6HXH)
| PDB | External Database | Details |
|---|---|---|
| Pro 485 | - | linker |
| Met 486 | - | linker |
| Gly 487 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 927044.1 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 12219.3 | |
| All* | Total formula weight | 939263.4 |
