6HXH
Structure of the human ATP citrate lyase holoenzyme in complex with citrate, coenzyme A and Mg.ADP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003878 | molecular_function | ATP citrate synthase activity |
| A | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| A | 0006101 | biological_process | citrate metabolic process |
| A | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003878 | molecular_function | ATP citrate synthase activity |
| B | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| B | 0006101 | biological_process | citrate metabolic process |
| B | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003878 | molecular_function | ATP citrate synthase activity |
| C | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| C | 0006101 | biological_process | citrate metabolic process |
| C | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003878 | molecular_function | ATP citrate synthase activity |
| D | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| D | 0006101 | biological_process | citrate metabolic process |
| D | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0003878 | molecular_function | ATP citrate synthase activity |
| E | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| E | 0006101 | biological_process | citrate metabolic process |
| E | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0003878 | molecular_function | ATP citrate synthase activity |
| F | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| F | 0006101 | biological_process | citrate metabolic process |
| F | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0003878 | molecular_function | ATP citrate synthase activity |
| G | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| G | 0006101 | biological_process | citrate metabolic process |
| G | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
| H | 0003824 | molecular_function | catalytic activity |
| H | 0003878 | molecular_function | ATP citrate synthase activity |
| H | 0006085 | biological_process | acetyl-CoA biosynthetic process |
| H | 0006101 | biological_process | citrate metabolic process |
| H | 0046912 | molecular_function | acyltransferase activity, acyl groups converted into alkyl on transfer |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 1201 |
| Chain | Residue |
| A | SER308 |
| A | GLU599 |
| A | PO41202 |
| A | FLC1203 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue PO4 A 1202 |
| Chain | Residue |
| A | GLY664 |
| A | GLY665 |
| A | HIS760 |
| A | MG1201 |
| A | FLC1203 |
| A | COA1204 |
| A | GLY281 |
| A | GLY282 |
| A | GLY283 |
| A | SER308 |
| A | SER663 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue FLC A 1203 |
| Chain | Residue |
| A | SER308 |
| A | GLY309 |
| A | SER343 |
| A | ALA345 |
| A | ASN346 |
| A | PHE347 |
| A | THR348 |
| A | ARG379 |
| A | MG1201 |
| A | PO41202 |
| A | COA1204 |
| site_id | AC4 |
| Number of Residues | 20 |
| Details | binding site for residue COA A 1204 |
| Chain | Residue |
| A | GLY261 |
| A | PHE533 |
| A | PHE572 |
| A | SER574 |
| A | ARG576 |
| A | SER577 |
| A | ILE597 |
| A | GLU599 |
| A | ALA624 |
| A | THR625 |
| A | VAL626 |
| A | PO41202 |
| A | FLC1203 |
| B | LYS964 |
| B | LEU969 |
| B | ILE970 |
| B | ILE973 |
| B | LYS1017 |
| B | LYS1018 |
| B | LEU1021 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | binding site for residue ADP A 1205 |
| Chain | Residue |
| A | VAL56 |
| A | LYS58 |
| A | ARG65 |
| A | ARG66 |
| A | GLY67 |
| A | PRO109 |
| A | PHE110 |
| A | VAL111 |
| A | HIS113 |
| A | GLU118 |
| A | VAL140 |
| A | ASN203 |
| A | PRO204 |
| A | LEU215 |
| A | ASP216 |
| A | MG1206 |
| A | HOH1302 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 1206 |
| Chain | Residue |
| A | ASN203 |
| A | ASP216 |
| A | ADP1205 |
| A | HOH1302 |
| site_id | AC7 |
| Number of Residues | 20 |
| Details | binding site for residue COA A 1207 |
| Chain | Residue |
| A | LYS964 |
| A | LEU969 |
| A | ILE970 |
| A | ILE973 |
| A | LYS1017 |
| A | LYS1018 |
| A | LEU1021 |
| B | GLY261 |
| B | PHE347 |
| B | PHE533 |
| B | PHE572 |
| B | ALA573 |
| B | SER574 |
| B | ARG576 |
| B | SER577 |
| B | ILE597 |
| B | ALA624 |
| B | THR625 |
| B | VAL626 |
| B | FLC1203 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 1201 |
| Chain | Residue |
| B | SER308 |
| B | GLU599 |
| B | PO41202 |
| B | FLC1203 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 B 1202 |
| Chain | Residue |
| B | MG1201 |
| B | FLC1203 |
| B | GLY281 |
| B | GLY282 |
| B | GLY283 |
| B | SER308 |
| B | SER663 |
| B | GLY664 |
| B | GLY665 |
| B | HIS760 |
| site_id | AD1 |
| Number of Residues | 11 |
| Details | binding site for residue FLC B 1203 |
| Chain | Residue |
| A | COA1207 |
| B | SER308 |
| B | GLY309 |
| B | SER343 |
| B | ALA345 |
| B | ASN346 |
| B | PHE347 |
| B | THR348 |
| B | ARG379 |
| B | MG1201 |
| B | PO41202 |
| site_id | AD2 |
| Number of Residues | 18 |
| Details | binding site for residue ADP B 1204 |
| Chain | Residue |
| B | VAL56 |
| B | LYS58 |
| B | ARG65 |
| B | ARG66 |
| B | GLY67 |
| B | PRO109 |
| B | PHE110 |
| B | VAL111 |
| B | HIS113 |
| B | GLU118 |
| B | VAL140 |
| B | ASN203 |
| B | PRO204 |
| B | LEU215 |
| B | ASP216 |
| B | MG1205 |
| B | HOH1301 |
| B | HOH1302 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 1205 |
| Chain | Residue |
| B | ASN203 |
| B | ASP216 |
| B | ADP1204 |
| B | HOH1301 |
| B | HOH1302 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue MG C 1201 |
| Chain | Residue |
| C | SER308 |
| C | GLU599 |
| C | PO41202 |
| C | FLC1203 |
| site_id | AD5 |
| Number of Residues | 11 |
| Details | binding site for residue PO4 C 1202 |
| Chain | Residue |
| C | GLY281 |
| C | GLY282 |
| C | GLY283 |
| C | SER308 |
| C | SER663 |
| C | GLY664 |
| C | GLY665 |
| C | HIS760 |
| C | MG1201 |
| C | FLC1203 |
| C | COA1204 |
| site_id | AD6 |
| Number of Residues | 11 |
| Details | binding site for residue FLC C 1203 |
| Chain | Residue |
| C | SER308 |
| C | GLY309 |
| C | SER343 |
| C | ALA345 |
| C | ASN346 |
| C | PHE347 |
| C | THR348 |
| C | ARG379 |
| C | MG1201 |
| C | PO41202 |
| C | COA1204 |
| site_id | AD7 |
| Number of Residues | 21 |
| Details | binding site for residue COA C 1204 |
| Chain | Residue |
| C | GLY261 |
| C | PHE533 |
| C | PHE572 |
| C | SER574 |
| C | ARG576 |
| C | SER577 |
| C | ILE597 |
| C | GLU599 |
| C | ALA624 |
| C | THR625 |
| C | VAL626 |
| C | GLY664 |
| C | PO41202 |
| C | FLC1203 |
| D | LYS964 |
| D | LEU969 |
| D | ILE970 |
| D | ILE973 |
| D | LYS1017 |
| D | LYS1018 |
| D | LEU1021 |
| site_id | AD8 |
| Number of Residues | 19 |
| Details | binding site for residue ADP C 1205 |
| Chain | Residue |
| C | VAL56 |
| C | LYS58 |
| C | ARG65 |
| C | ARG66 |
| C | GLY67 |
| C | VAL72 |
| C | PHE110 |
| C | VAL111 |
| C | HIS113 |
| C | GLU118 |
| C | GLY139 |
| C | VAL140 |
| C | ASN203 |
| C | PRO204 |
| C | LEU215 |
| C | ASP216 |
| C | MG1206 |
| C | HOH1301 |
| C | HOH1302 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 1206 |
| Chain | Residue |
| C | ASN203 |
| C | ASP216 |
| C | ADP1205 |
| C | HOH1301 |
| C | HOH1302 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 1201 |
| Chain | Residue |
| D | SER308 |
| D | GLU599 |
| D | PO41202 |
| D | FLC1203 |
| site_id | AE2 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 D 1202 |
| Chain | Residue |
| D | GLY281 |
| D | GLY282 |
| D | GLY283 |
| D | SER308 |
| D | SER663 |
| D | GLY664 |
| D | GLY665 |
| D | HIS760 |
| D | MG1201 |
| D | FLC1203 |
| site_id | AE3 |
| Number of Residues | 12 |
| Details | binding site for residue FLC D 1203 |
| Chain | Residue |
| D | ALA280 |
| D | SER308 |
| D | GLY309 |
| D | SER343 |
| D | ALA345 |
| D | ASN346 |
| D | PHE347 |
| D | THR348 |
| D | ARG379 |
| D | MG1201 |
| D | PO41202 |
| D | COA1204 |
| site_id | AE4 |
| Number of Residues | 20 |
| Details | binding site for residue COA D 1204 |
| Chain | Residue |
| C | LYS964 |
| C | LEU969 |
| C | ILE970 |
| C | ILE973 |
| C | LYS1017 |
| C | LYS1018 |
| C | LEU1021 |
| D | GLY261 |
| D | PHE533 |
| D | PHE572 |
| D | SER574 |
| D | ARG576 |
| D | SER577 |
| D | ILE597 |
| D | GLU599 |
| D | ALA624 |
| D | THR625 |
| D | VAL626 |
| D | GLY664 |
| D | FLC1203 |
| site_id | AE5 |
| Number of Residues | 18 |
| Details | binding site for residue ADP D 1205 |
| Chain | Residue |
| D | VAL56 |
| D | LYS58 |
| D | ARG65 |
| D | ARG66 |
| D | GLY67 |
| D | PRO109 |
| D | PHE110 |
| D | VAL111 |
| D | HIS113 |
| D | GLU118 |
| D | VAL140 |
| D | ASN203 |
| D | PRO204 |
| D | LEU215 |
| D | ASP216 |
| D | MG1206 |
| D | HOH1301 |
| D | HOH1302 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 1206 |
| Chain | Residue |
| D | ASN203 |
| D | ASP216 |
| D | ADP1205 |
| D | HOH1301 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 1201 |
| Chain | Residue |
| E | SER308 |
| E | GLU599 |
| E | PO41202 |
| E | FLC1203 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 E 1202 |
| Chain | Residue |
| E | GLY282 |
| E | GLY283 |
| E | SER308 |
| E | SER663 |
| E | GLY664 |
| E | GLY665 |
| E | HIS760 |
| E | MG1201 |
| E | FLC1203 |
| site_id | AE9 |
| Number of Residues | 11 |
| Details | binding site for residue FLC E 1203 |
| Chain | Residue |
| E | SER308 |
| E | GLY309 |
| E | SER343 |
| E | ALA345 |
| E | ASN346 |
| E | PHE347 |
| E | THR348 |
| E | ARG379 |
| E | MG1201 |
| E | PO41202 |
| E | COA1204 |
| site_id | AF1 |
| Number of Residues | 19 |
| Details | binding site for residue COA E 1204 |
| Chain | Residue |
| E | GLY261 |
| E | PHE533 |
| E | PHE572 |
| E | SER574 |
| E | ARG576 |
| E | SER577 |
| E | ILE597 |
| E | GLU599 |
| E | ALA624 |
| E | THR625 |
| E | VAL626 |
| E | FLC1203 |
| F | LYS964 |
| F | LEU969 |
| F | ILE970 |
| F | ILE973 |
| F | LYS1017 |
| F | LYS1018 |
| F | LEU1021 |
| site_id | AF2 |
| Number of Residues | 16 |
| Details | binding site for residue ADP E 1205 |
| Chain | Residue |
| E | VAL56 |
| E | LYS58 |
| E | ARG65 |
| E | ARG66 |
| E | GLY67 |
| E | PRO109 |
| E | VAL111 |
| E | HIS113 |
| E | GLU118 |
| E | VAL140 |
| E | ASN203 |
| E | PRO204 |
| E | LEU215 |
| E | ASP216 |
| E | MG1206 |
| E | HOH1301 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 1206 |
| Chain | Residue |
| E | ASN203 |
| E | ASP216 |
| E | ADP1205 |
| E | HOH1301 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue MG F 1201 |
| Chain | Residue |
| F | SER308 |
| F | GLU599 |
| F | PO41202 |
| F | FLC1203 |
| site_id | AF5 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 F 1202 |
| Chain | Residue |
| F | GLY281 |
| F | GLY282 |
| F | GLY283 |
| F | SER308 |
| F | SER663 |
| F | GLY664 |
| F | GLY665 |
| F | HIS760 |
| F | MG1201 |
| F | FLC1203 |
| site_id | AF6 |
| Number of Residues | 10 |
| Details | binding site for residue FLC F 1203 |
| Chain | Residue |
| F | SER308 |
| F | GLY309 |
| F | ALA345 |
| F | ASN346 |
| F | PHE347 |
| F | THR348 |
| F | ARG379 |
| F | MG1201 |
| F | PO41202 |
| F | COA1204 |
| site_id | AF7 |
| Number of Residues | 19 |
| Details | binding site for residue COA F 1204 |
| Chain | Residue |
| E | LYS964 |
| E | LEU969 |
| E | ILE970 |
| E | ILE973 |
| E | LYS1017 |
| E | LYS1018 |
| E | LEU1021 |
| F | GLY261 |
| F | PHE533 |
| F | PHE572 |
| F | SER574 |
| F | ARG576 |
| F | SER577 |
| F | ILE597 |
| F | GLU599 |
| F | ALA624 |
| F | THR625 |
| F | VAL626 |
| F | FLC1203 |
| site_id | AF8 |
| Number of Residues | 16 |
| Details | binding site for residue ADP F 1205 |
| Chain | Residue |
| F | VAL56 |
| F | LYS58 |
| F | ARG65 |
| F | ARG66 |
| F | GLY67 |
| F | PRO109 |
| F | VAL111 |
| F | HIS113 |
| F | GLU118 |
| F | VAL140 |
| F | ASN203 |
| F | PRO204 |
| F | LEU215 |
| F | ASP216 |
| F | MG1206 |
| F | HOH1301 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue MG F 1206 |
| Chain | Residue |
| F | ASN203 |
| F | ASP216 |
| F | ADP1205 |
| F | HOH1301 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue MG G 1201 |
| Chain | Residue |
| G | SER308 |
| G | GLU599 |
| G | PO41202 |
| G | FLC1203 |
| site_id | AG2 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 G 1202 |
| Chain | Residue |
| G | GLY281 |
| G | GLY282 |
| G | GLY283 |
| G | SER308 |
| G | SER663 |
| G | GLY664 |
| G | GLY665 |
| G | HIS760 |
| G | MG1201 |
| G | FLC1203 |
| site_id | AG3 |
| Number of Residues | 11 |
| Details | binding site for residue FLC G 1203 |
| Chain | Residue |
| G | SER308 |
| G | GLY309 |
| G | SER343 |
| G | ALA345 |
| G | ASN346 |
| G | PHE347 |
| G | THR348 |
| G | ARG379 |
| G | MG1201 |
| G | PO41202 |
| G | COA1204 |
| site_id | AG4 |
| Number of Residues | 19 |
| Details | binding site for residue COA G 1204 |
| Chain | Residue |
| G | GLY261 |
| G | PHE533 |
| G | PHE572 |
| G | SER574 |
| G | ARG576 |
| G | SER577 |
| G | ILE597 |
| G | GLU599 |
| G | ALA624 |
| G | THR625 |
| G | VAL626 |
| G | FLC1203 |
| H | LYS964 |
| H | LEU969 |
| H | ILE970 |
| H | ILE973 |
| H | LYS1017 |
| H | LYS1018 |
| H | LEU1021 |
| site_id | AG5 |
| Number of Residues | 17 |
| Details | binding site for residue ADP G 1205 |
| Chain | Residue |
| G | VAL56 |
| G | LYS58 |
| G | ARG65 |
| G | ARG66 |
| G | GLY67 |
| G | PRO109 |
| G | PHE110 |
| G | VAL111 |
| G | HIS113 |
| G | GLU118 |
| G | VAL140 |
| G | ASN203 |
| G | PRO204 |
| G | LEU215 |
| G | ASP216 |
| G | MG1206 |
| G | HOH1302 |
| site_id | AG6 |
| Number of Residues | 5 |
| Details | binding site for residue MG G 1206 |
| Chain | Residue |
| G | ASN203 |
| G | ASP216 |
| G | ADP1205 |
| G | HOH1301 |
| G | HOH1302 |
| site_id | AG7 |
| Number of Residues | 4 |
| Details | binding site for residue MG H 1201 |
| Chain | Residue |
| H | SER308 |
| H | GLU599 |
| H | PO41202 |
| H | FLC1203 |
| site_id | AG8 |
| Number of Residues | 11 |
| Details | binding site for residue PO4 H 1202 |
| Chain | Residue |
| H | GLY281 |
| H | GLY282 |
| H | GLY283 |
| H | SER308 |
| H | SER663 |
| H | GLY664 |
| H | GLY665 |
| H | HIS760 |
| H | MG1201 |
| H | FLC1203 |
| H | COA1204 |
| site_id | AG9 |
| Number of Residues | 12 |
| Details | binding site for residue FLC H 1203 |
| Chain | Residue |
| H | ALA280 |
| H | SER308 |
| H | GLY309 |
| H | SER343 |
| H | ALA345 |
| H | ASN346 |
| H | PHE347 |
| H | THR348 |
| H | ARG379 |
| H | MG1201 |
| H | PO41202 |
| H | COA1204 |
| site_id | AH1 |
| Number of Residues | 20 |
| Details | binding site for residue COA H 1204 |
| Chain | Residue |
| G | LYS964 |
| G | LEU969 |
| G | ILE970 |
| G | ILE973 |
| G | LYS1017 |
| G | LYS1018 |
| G | LEU1021 |
| H | GLY261 |
| H | PHE533 |
| H | PHE572 |
| H | SER574 |
| H | ARG576 |
| H | SER577 |
| H | ILE597 |
| H | GLU599 |
| H | ALA624 |
| H | THR625 |
| H | GLY664 |
| H | PO41202 |
| H | FLC1203 |
| site_id | AH2 |
| Number of Residues | 19 |
| Details | binding site for residue ADP H 1205 |
| Chain | Residue |
| H | VAL56 |
| H | LYS58 |
| H | LYS64 |
| H | ARG65 |
| H | ARG66 |
| H | GLY67 |
| H | PRO109 |
| H | VAL111 |
| H | HIS113 |
| H | GLU118 |
| H | GLY139 |
| H | VAL140 |
| H | ASN203 |
| H | PRO204 |
| H | LEU215 |
| H | ASP216 |
| H | MG1206 |
| H | HOH1301 |
| H | HOH1302 |
| site_id | AH3 |
| Number of Residues | 5 |
| Details | binding site for residue MG H 1206 |
| Chain | Residue |
| H | ASN203 |
| H | ASP216 |
| H | ADP1205 |
| H | HOH1301 |
| H | HOH1302 |
Functional Information from PROSITE/UniProt
| site_id | PS00399 |
| Number of Residues | 17 |
| Details | SUCCINYL_COA_LIG_2 ATP-citrate lyase / succinyl-CoA ligases family active site. GtcAtmfssevQFGHAG |
| Chain | Residue | Details |
| A | GLY746-GLY762 |
| site_id | PS01216 |
| Number of Residues | 30 |
| Details | SUCCINYL_COA_LIG_1 ATP-citrate lyase / succinyl-CoA ligases family signature 1. SRSGGMSnElnniisrttdGvyegVAIGGD |
| Chain | Residue | Details |
| A | SER661-ASP690 |
| site_id | PS01217 |
| Number of Residues | 25 |
| Details | SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GrIwtMvAGGGASvvysDtIcdl.GG |
| Chain | Residue | Details |
| A | GLY273-GLY297 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000305|PubMed:1371749 |
| Chain | Residue | Details |
| A | HIS760 | |
| B | HIS760 | |
| C | HIS760 | |
| D | HIS760 | |
| E | HIS760 | |
| F | HIS760 | |
| G | HIS760 | |
| H | HIS760 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:22102020 |
| Chain | Residue | Details |
| A | LYS58 | |
| B | GLY67 | |
| B | PRO109 | |
| B | VAL111 | |
| B | GLU118 | |
| B | ASP216 | |
| C | LYS58 | |
| C | ARG66 | |
| C | GLY67 | |
| C | PRO109 | |
| C | VAL111 | |
| A | ARG66 | |
| C | GLU118 | |
| C | ASP216 | |
| D | LYS58 | |
| D | ARG66 | |
| D | GLY67 | |
| D | PRO109 | |
| D | VAL111 | |
| D | GLU118 | |
| D | ASP216 | |
| E | LYS58 | |
| A | GLY67 | |
| E | ARG66 | |
| E | GLY67 | |
| E | PRO109 | |
| E | VAL111 | |
| E | GLU118 | |
| E | ASP216 | |
| F | LYS58 | |
| F | ARG66 | |
| F | GLY67 | |
| F | PRO109 | |
| A | PRO109 | |
| F | VAL111 | |
| F | GLU118 | |
| F | ASP216 | |
| G | LYS58 | |
| G | ARG66 | |
| G | GLY67 | |
| G | PRO109 | |
| G | VAL111 | |
| G | GLU118 | |
| G | ASP216 | |
| A | VAL111 | |
| H | LYS58 | |
| H | ARG66 | |
| H | GLY67 | |
| H | PRO109 | |
| H | VAL111 | |
| H | GLU118 | |
| H | ASP216 | |
| A | GLU118 | |
| A | ASP216 | |
| B | LYS58 | |
| B | ARG66 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20558738, ECO:0000269|PubMed:22102020 |
| Chain | Residue | Details |
| A | ASP257 | |
| D | ASP257 | |
| D | SER260 | |
| D | ALA262 | |
| E | ASP257 | |
| E | SER260 | |
| E | ALA262 | |
| F | ASP257 | |
| F | SER260 | |
| F | ALA262 | |
| G | ASP257 | |
| A | SER260 | |
| G | SER260 | |
| G | ALA262 | |
| H | ASP257 | |
| H | SER260 | |
| H | ALA262 | |
| A | ALA262 | |
| B | ASP257 | |
| B | SER260 | |
| B | ALA262 | |
| C | ASP257 | |
| C | SER260 | |
| C | ALA262 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20558738 |
| Chain | Residue | Details |
| A | GLY309 | |
| B | ARG379 | |
| C | GLY309 | |
| C | ASN346 | |
| C | THR348 | |
| C | TYR364 | |
| C | ARG379 | |
| D | GLY309 | |
| D | ASN346 | |
| D | THR348 | |
| D | TYR364 | |
| A | ASN346 | |
| D | ARG379 | |
| E | GLY309 | |
| E | ASN346 | |
| E | THR348 | |
| E | TYR364 | |
| E | ARG379 | |
| F | GLY309 | |
| F | ASN346 | |
| F | THR348 | |
| F | TYR364 | |
| A | THR348 | |
| F | ARG379 | |
| G | GLY309 | |
| G | ASN346 | |
| G | THR348 | |
| G | TYR364 | |
| G | ARG379 | |
| H | GLY309 | |
| H | ASN346 | |
| H | THR348 | |
| H | TYR364 | |
| A | TYR364 | |
| H | ARG379 | |
| A | ARG379 | |
| B | GLY309 | |
| B | ASN346 | |
| B | THR348 | |
| B | TYR364 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU779 | |
| B | LEU779 | |
| C | LEU779 | |
| D | LEU779 | |
| E | LEU779 | |
| F | LEU779 | |
| G | LEU779 | |
| H | LEU779 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
| Chain | Residue | Details |
| A | TYR131 | |
| B | TYR131 | |
| C | TYR131 | |
| D | TYR131 | |
| E | TYR131 | |
| F | TYR131 | |
| G | TYR131 | |
| H | TYR131 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q91V92 |
| Chain | Residue | Details |
| A | SER263 | |
| B | SER263 | |
| C | SER263 | |
| D | SER263 | |
| E | SER263 | |
| F | SER263 | |
| G | SER263 | |
| H | SER263 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:23932781 |
| Chain | Residue | Details |
| A | LYS540 | |
| B | LYS540 | |
| C | LYS540 | |
| D | LYS540 | |
| E | LYS540 | |
| F | LYS540 | |
| G | LYS540 | |
| H | LYS540 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:23932781, ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS546 | |
| E | LYS554 | |
| F | LYS546 | |
| F | LYS554 | |
| G | LYS546 | |
| G | LYS554 | |
| H | LYS546 | |
| H | LYS554 | |
| A | LYS554 | |
| B | LYS546 | |
| B | LYS554 | |
| C | LYS546 | |
| C | LYS554 | |
| D | LYS546 | |
| D | LYS554 | |
| E | LYS546 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | THR639 | |
| B | THR639 | |
| C | THR639 | |
| D | THR639 | |
| E | THR639 | |
| F | THR639 | |
| G | THR639 | |
| H | THR639 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 16 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | SER663 | |
| E | SER839 | |
| F | SER663 | |
| F | SER839 | |
| G | SER663 | |
| G | SER839 | |
| H | SER663 | |
| H | SER839 | |
| A | SER839 | |
| B | SER663 | |
| B | SER839 | |
| C | SER663 | |
| C | SER839 | |
| D | SER663 | |
| D | SER839 | |
| E | SER663 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | TYR682 | |
| B | TYR682 | |
| C | TYR682 | |
| D | TYR682 | |
| E | TYR682 | |
| F | TYR682 | |
| G | TYR682 | |
| H | TYR682 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 24 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS948 | |
| D | LYS948 | |
| D | LYS968 | |
| D | LYS1077 | |
| E | LYS948 | |
| E | LYS968 | |
| E | LYS1077 | |
| F | LYS948 | |
| F | LYS968 | |
| F | LYS1077 | |
| G | LYS948 | |
| A | LYS968 | |
| G | LYS968 | |
| G | LYS1077 | |
| H | LYS948 | |
| H | LYS968 | |
| H | LYS1077 | |
| A | LYS1077 | |
| B | LYS948 | |
| B | LYS968 | |
| B | LYS1077 | |
| C | LYS948 | |
| C | LYS968 | |
| C | LYS1077 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q91V92 |
| Chain | Residue | Details |
| A | LYS978 | |
| B | LYS978 | |
| C | LYS978 | |
| D | LYS978 | |
| E | LYS978 | |
| F | LYS978 | |
| G | LYS978 | |
| H | LYS978 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195 |
| Chain | Residue | Details |
| A | SER1100 | |
| B | SER1100 | |
| C | SER1100 | |
| D | SER1100 | |
| E | SER1100 | |
| F | SER1100 | |
| G | SER1100 | |
| H | SER1100 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 32 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000269|PubMed:27664236, ECO:0000305|PubMed:23932781 |
| Chain | Residue | Details |
| A | LYS540 | |
| C | LYS546 | |
| C | LYS554 | |
| D | LYS540 | |
| D | LYS546 | |
| D | LYS554 | |
| E | LYS540 | |
| E | LYS546 | |
| E | LYS554 | |
| F | LYS540 | |
| F | LYS546 | |
| F | LYS554 | |
| G | LYS540 | |
| G | LYS546 | |
| G | LYS554 | |
| H | LYS540 | |
| A | LYS546 | |
| H | LYS546 | |
| H | LYS554 | |
| A | LYS554 | |
| B | LYS540 | |
| B | LYS546 | |
| B | LYS554 | |
| C | LYS540 |
