6FS1
MCL1 in complex with an indole acid ligand
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Induced myeloid leukemia cell differentiation protein Mcl-1 | polymer | 150 | 17086.4 | 2 | UniProt (Q07820) Pfam (PF00452) In PDB | Homo sapiens (Human) | Bcl-2-like protein 3,Bcl2-L-3,Bcl-2-related protein EAT/mcl1,mcl1/EAT |
2 | A, B | 7-[3-[(1,5-dimethylpyrazol-3-yl)methylsulfanylmethyl]-1,5-dimethyl-pyrazol-4-yl]-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid | non-polymer | 593.7 | 2 | Chemie (E4Q) | |||
3 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
4 | water | water | 18.0 | 383 | Chemie (HOH) |
Sequence modifications
A, B: 174 - 321 (UniProt: Q07820)
PDB | External Database | Details |
---|---|---|
Asp 172 | - | expression tag |
Asp 173 | - | expression tag |
Ser 193 | Ala 193 | conflict |
Ser 196 | Thr 196 | conflict |
Leu 199 | Met 199 | conflict |
Glu 201 | Arg 201 | conflict |
Ala 202 | Ser 202 | conflict |
Ala 205 | Thr 205 | conflict |
Gly 206 | Ser 206 | conflict |
Arg 208 | Lys 208 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 34172.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1311.6 | |
All* | Total formula weight | 35484.5 |