6E7S

Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-5

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Glutamate receptor ionotropic, NMDA 1	polymer	385	43162.3	2	UniProt (A0A1L8F5J9) Pfam (PF01094) In PDB	Xenopus laevis (African clawed frog)	GluN1,N-methyl-D-aspartate receptor subunit NR1,NMD-R1
2	B, D	Glutamate receptor ionotropic, NMDA 2B	polymer	363	41280.8	2	UniProt (Q00960) Pfam (PF01094) In PDB	Rattus norvegicus (Rat)	GluN2B,Glutamate [NMDA] receptor subunit epsilon-2,N-methyl D-aspartate receptor subtype 2B,NR2B
3	E	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
4	F	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	A, B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
6	A, C	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
7	A, B, C, D	CHLORIDE ION	non-polymer		35.5	8	Chemie (CL)
8	B, D	N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl](ethyl)amino}-2-hydroxypropoxy]phenyl}methanesulfonamide	non-polymer		461.4	2	Chemie (HZ4)
9		water	water		18.0	178	Chemie (HOH)

Sequence modifications

A, C: 23 - 407 (UniProt: A0A1L8F5J9)

PDB	External Database	Details
Gln 61	Asn 61	engineered mutation
Gln 371	Asn 371	engineered mutation

B, D: 32 - 394 (UniProt: Q00960)

PDB	External Database	Details
Asp 348	Asn 348	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	168886.2
Branched	Number of molecules	2
	Total formula weight	1335.2
Non-Polymers*	Number of molecules	20
	Total formula weight	3022.1
All*	Total formula weight	173243.5

*Water molecules are not included.