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6E7S

Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-5

Summary for 6E7S
Entry DOI10.2210/pdb6e7s/pdb
DescriptorGlutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2B, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywordsnmda receptor, ion channel, allosteric modulation, extracellular domain, transport protein
Biological sourceXenopus laevis (African clawed frog)
More
Total number of polymer chains4
Total formula weight173243.48
Authors
Regan, M.C.,Furukawa, H. (deposition date: 2018-07-27, release date: 2019-01-30, Last modification date: 2023-10-11)
Primary citationRegan, M.C.,Furukawa, H.
Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors
Nat Commun, 10:321-, 2019
Experimental method
X-RAY DIFFRACTION (2.72 Å)
Structure validation

217705

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