6E7K
Structure of the lipoprotein lipase GPIHBP1 complex that mediates plasma triglyceride hydrolysis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Lipoprotein lipase | polymer | 448 | 50379.0 | 2 | UniProt (P06858) Pfam (PF00151) Pfam (PF01477) In PDB | Homo sapiens (Human) | LPL |
| 2 | C, D | Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 | polymer | 131 | 14725.8 | 2 | UniProt (Q8IV16) Pfam (PF00021) In PDB | Homo sapiens (Human) | GPIHBP1, GPI-anchored HDL-binding protein 1, High density lipoprotein-binding protein 1 |
| 3 | E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | F | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 5 | G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 1 | In PDB GlyTouCan (G21290RB) | |||
| 6 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 7 | B, C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 8 | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A, B: 28 - 475 (UniProt: P06858)
| PDB | External Database | Details |
|---|---|---|
| Ala 324 | Arg 324 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130209.6 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1889.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 522.6 | |
| All* | Total formula weight | 132621.9 |
