6DMO
Cryo-EM structure of human Ptch1 with three mutations L282Q/T500F/P504L
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein patched homolog 1 | polymer | 1349 | 150266.7 | 1 | UniProt (Q13635) Pfam (PF02460) In PDB | Homo sapiens (Human) | PTC1 |
| 2 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) |
Sequence modifications
A: 1 - 1305 (UniProt: Q13635)
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | initiating methionine |
| Ala -19 | - | expression tag |
| Asp -18 | - | expression tag |
| Tyr -17 | - | expression tag |
| Lys -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Asp -14 | - | expression tag |
| Asp -13 | - | expression tag |
| Asp -12 | - | expression tag |
| Lys -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Pro -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Val -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Gln 282 | Leu 282 | engineered mutation |
| Phe 500 | Thr 500 | engineered mutation |
| Leu 504 | Pro 504 | engineered mutation |
| Leu 1306 | - | expression tag |
| Glu 1307 | - | expression tag |
| Gly 1308 | - | expression tag |
| Ser 1309 | - | expression tag |
| Asp 1310 | - | expression tag |
| Glu 1311 | - | expression tag |
| Val 1312 | - | expression tag |
| Asp 1313 | - | expression tag |
| Ala 1314 | - | expression tag |
| Val 1315 | - | expression tag |
| Glu 1316 | - | expression tag |
| Gly 1317 | - | expression tag |
| Ser 1318 | - | expression tag |
| His 1319 | - | expression tag |
| His 1320 | - | expression tag |
| His 1321 | - | expression tag |
| His 1322 | - | expression tag |
| His 1323 | - | expression tag |
| His 1324 | - | expression tag |
| His 1325 | - | expression tag |
| His 1326 | - | expression tag |
| His 1327 | - | expression tag |
| His 1328 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 150266.7 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1106.0 | |
| All* | Total formula weight | 151797.1 |
